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PDB: 785 results

1HMP
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BU of 1hmp by Molmil
THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP
Descriptor: GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE GUANINE PHOSPHORIBOSYL-TRANSFERASE
Authors:Eads, J.C, Scapin, G, Xu, Y, Grubmeyer, C, Sacchettini, J.C.
Deposit date:1994-06-03
Release date:1995-06-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.
Cell(Cambridge,Mass.), 78, 1994
8Y53
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Cryo-EM structure of the MK-5046-bound BRS3-Gq complex
Descriptor: (2~{S})-1,1,1-tris(fluoranyl)-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1~{H}-imidazol-2-yl]propan-2-ol, Bombesin receptor subtype-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Li, C, Xu, Y, Yin, W, Xu, H.E.
Deposit date:2024-01-31
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3.
Cell Rep, 43, 2024
8Y52
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Cryo-EM structure of the BA1-bound BRS3-Gq complex
Descriptor: BA1, Bombesin receptor subtype-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Li, C, Xu, Y, Yin, W, Xu, H.E.
Deposit date:2024-01-31
Release date:2024-09-11
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3.
Cell Rep, 43, 2024
4MXC
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BU of 4mxc by Molmil
Crystal structure of CMET in complex with novel inhibitor
Descriptor: Hepatocyte growth factor receptor, N-(3-fluoro-4-{[2-({3-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Authors:Liu, Q.F, Chen, T.T, Xu, Y.C.
Deposit date:2013-09-26
Release date:2014-10-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.632 Å)
Cite:Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity
ACS MED.CHEM.LETT., 5, 2014
7XHE
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Crystal structure of CBP bromodomain liganded with CCS151
Descriptor: (6S)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]-1-(3-fluoranyl-4-methoxy-phenyl)piperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein
Authors:Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y.
Deposit date:2022-04-08
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain
Biochem.Biophys.Res.Commun., 623, 2022
7XH6
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BU of 7xh6 by Molmil
Crystal structure of CBP bromodomain liganded with CCS1477
Descriptor: (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, CREB-binding protein, DIMETHYL SULFOXIDE, ...
Authors:Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y.
Deposit date:2022-04-07
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain
Biochem.Biophys.Res.Commun., 623, 2022
7XI0
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BU of 7xi0 by Molmil
Crystal structure of CBP bromodomain liganded with CCS150
Descriptor: (6S)-1-(3-chloranyl-4-methoxy-phenyl)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]piperidin-2-one, CREB-binding protein, GLYCEROL
Authors:Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y.
Deposit date:2022-04-11
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain
Biochem.Biophys.Res.Commun., 623, 2022
6M08
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BU of 6m08 by Molmil
Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor.
Descriptor: (2S)-2-[(Z)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid, Platelet-activating factor acetylhydrolase
Authors:Hu, H.C, Xu, Y.C.
Deposit date:2020-02-20
Release date:2020-12-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach.
J.Med.Chem., 63, 2020
6M07
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BU of 6m07 by Molmil
Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor
Descriptor: (2S)-2-[(E)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)-2-[2,2,2-tris(fluoranyl)ethoxy]phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid, Platelet-activating factor acetylhydrolase
Authors:Hu, H.C, Xu, Y.C.
Deposit date:2020-02-20
Release date:2020-12-30
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach.
J.Med.Chem., 63, 2020
2A7P
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BU of 2a7p by Molmil
Crystal Structure of the G81A mutant of the Active Chimera of (S)-Mandelate Dehydrogenase in complex with its substrate 3-indolelactate
Descriptor: (S)-Mandelate Dehydrogenase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(INDOL-3-YL) LACTATE, ...
Authors:Sukumar, N, Xu, Y, Mitra, B, Mathews, F.S.
Deposit date:2005-07-05
Release date:2006-07-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of the G81A mutant form of the active chimera of (S)-mandelate dehydrogenase and its complex with two of its substrates.
Acta Crystallogr.,Sect.D, 65, 2009
8J0I
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BU of 8j0i by Molmil
Aldo-keto reductase KmAKR
Descriptor: NADPH-dependent alpha-keto amide reductase, SODIUM ION
Authors:Xu, S.Y, Zhou, L, Xu, Y, Wang, Y.J, Zheng, Y.G.
Deposit date:2023-04-11
Release date:2024-04-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Aldo-keto reductase KmAKR from Kluyveromyces marxianus
To Be Published
6HN5
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BU of 6hn5 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
Authors:Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
Deposit date:2018-09-14
Release date:2018-11-21
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
6LRC
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BU of 6lrc by Molmil
Human cGAS catalytic domain bound with the inhibitor PF-06928215
Descriptor: (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION
Authors:Zhao, W.F, Xu, Y.C.
Deposit date:2020-01-15
Release date:2020-06-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.831 Å)
Cite:In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J.Chem.Inf.Model., 60, 2020
8YHF
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BU of 8yhf by Molmil
The Crystal Structure of the Type I TGF beta receptor from Biortus.
Descriptor: 2-fluoranyl-~{N}-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1~{H}-imidazol-2-yl]methyl]aniline, TGF-beta receptor type-1
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y.
Deposit date:2024-02-28
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of the Type I TGF beta receptor from Biortus.
To Be Published
8YGY
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BU of 8ygy by Molmil
Structure of the KLK1 from Biortus.
Descriptor: 1,2-ETHANEDIOL, Kallikrein-1, SULFATE ION, ...
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y.
Deposit date:2024-02-27
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Structure of the KLK1 from Biortus.
To Be Published
8YHW
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BU of 8yhw by Molmil
The Crystal Structure of NF-kB-inducing Kinase (NIK) from Biortus
Descriptor: 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, MAGNESIUM ION, ...
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y.
Deposit date:2024-02-28
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of NF-kB-inducing Kinase (NIK) from Biortus
To Be Published
8YHL
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BU of 8yhl by Molmil
The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus
Descriptor: 1,2-ETHANEDIOL, 2-fluoranyl-~{N}-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1~{H}-imidazol-2-yl]methyl]aniline, ACETATE ION, ...
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y.
Deposit date:2024-02-28
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus
To Be Published
8XVV
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BU of 8xvv by Molmil
The TRRAP module of human NuA4/TIP60 complex
Descriptor: INOSITOL HEXAKISPHOSPHATE, Isoform 2 of E1A-binding protein p400, Isoform 2 of Transformation/transcription domain-associated protein
Authors:Chen, K, Wang, L, Yu, Z, Yu, J, Ren, Y, Wang, Q, Xu, Y.
Deposit date:2024-01-15
Release date:2024-07-24
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human TIP60 complex.
Nat Commun, 15, 2024
8XVG
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BU of 8xvg by Molmil
Structure of human NuA4/TIP60 complex
Descriptor: ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, Actin-like protein 6A, ...
Authors:Chen, K, Wang, L, Yu, Z, Yu, J, Ren, Y, Wang, Q, Xu, Y.
Deposit date:2024-01-15
Release date:2024-07-24
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (9.4 Å)
Cite:Structure of the human TIP60 complex.
Nat Commun, 15, 2024
8XVT
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BU of 8xvt by Molmil
The core subcomplex of human NuA4/TIP60 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ...
Authors:Chen, K, Wang, L, Yu, Z, Yu, J, Ren, Y, Wang, Q, Xu, Y.
Deposit date:2024-01-15
Release date:2024-07-24
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human TIP60 complex.
Nat Commun, 15, 2024
6P72
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BU of 6p72 by Molmil
Crystal Structure of the Cedar henipavirus Attachment G Glycoprotein global domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Attachment glycoprotein, ...
Authors:Xu, K, Nikolov, D.B, Xu, Y.
Deposit date:2019-06-04
Release date:2019-09-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.283 Å)
Cite:Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus.
Proc.Natl.Acad.Sci.USA, 116, 2019
6P7S
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BU of 6p7s by Molmil
Crystal Structure of the Cedar henipavirus Attachment G Glycoprotein globular domain in complex with the receptor ephrin-B1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Attachment glycoprotein, ...
Authors:Xu, K, Nikolov, D.B, Xu, Y.
Deposit date:2019-06-06
Release date:2019-09-25
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus.
Proc.Natl.Acad.Sci.USA, 116, 2019
6P7Y
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BU of 6p7y by Molmil
Crystal Structure of the Cedar henipavirus Attachment G Glycoprotein globular domain in complex with the receptor ephrin-B2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Attachment glycoprotein, ...
Authors:Xu, K, Nikolov, D.B, Xu, Y.
Deposit date:2019-06-06
Release date:2019-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus.
Proc.Natl.Acad.Sci.USA, 116, 2019
8AZ3
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BU of 8az3 by Molmil
IAPP S20G growth-phase fibril polymorph 4PF-CU
Descriptor: Islet amyloid polypeptide
Authors:Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A.
Deposit date:2022-09-05
Release date:2024-01-10
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural evolution of fibril polymorphs during amyloid assembly.
Cell, 186, 2023
8AZ4
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BU of 8az4 by Molmil
IAPP S20G plateau-phase fibril polymorph 2PF-L
Descriptor: Islet amyloid polypeptide
Authors:Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A.
Deposit date:2022-09-05
Release date:2024-01-10
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structural evolution of fibril polymorphs during amyloid assembly.
Cell, 186, 2023

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