4MXC

Crystal structure of CMET in complex with novel inhibitor

Summary for 4MXC

Entry DOI	10.2210/pdb4mxc/pdb
Descriptor	Hepatocyte growth factor receptor, N-(3-fluoro-4-{[2-({3-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (3 entities in total)
Functional Keywords	cmet inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains	1
Total formula weight	36627.19
Authors	Liu, Q.F.,Chen, T.T.,Xu, Y.C. (deposition date: 2013-09-26, release date: 2014-10-15, Last modification date: 2024-03-20)
Primary citation	Zhan, Z.S.,Ai, J.,Liu, Q.F.,Ji, Y.C.,Chen, T.T.,Xu, Y.C.,Geng, M.Y.,Duan, W.H. Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity ACS MED.CHEM.LETT., 5:673-678, 2014 Cited by PubMed: 24944742 DOI: 10.1021/ml500066m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.632 Å)

Structure validation