8AZ4

IAPP S20G plateau-phase fibril polymorph 2PF-L

Summary for 8AZ4

• Entry DOI: 10.2210/pdb8az4/pdb
• Related: 8AZ0
• EMDB information: 15728 15753 15754 15755 15756
• Descriptor: Islet amyloid polypeptide (2 entities in total)
• Functional Keywords: amyloid, fibril, helical, cross-beta, amylin, polymorph, islet, protein fibril, diabetes
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 38772.86

Authors

Wilkinson, M.,Xu, Y.,Gallardo, R.,Radford, S.E.,Ranson, N.A. (deposition date: 2022-09-05, release date: 2024-01-10)

• Primary citation: Wilkinson, M.,Xu, Y.,Thacker, D.,Taylor, A.I.P.,Fisher, D.G.,Gallardo, R.U.,Radford, S.E.,Ranson, N.A.; Structural evolution of fibril polymorphs during amyloid assembly.; Cell, 186:5798-5811.e26, 2023; PubMed: 38134875; DOI: 10.1016/j.cell.2023.11.025

Experimental method

ELECTRON MICROSCOPY (2.2 Å)