2A07
| Crystal Structure of Foxp2 bound Specifically to DNA. | 分子名称: | 5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3', 5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3', Forkhead box protein P2, ... | 著者 | Stroud, J.C, Wu, Y, Bates, D.L, Han, A, Nowick, K, Paabo, S, Tong, H, Chen, L. | 登録日 | 2005-06-16 | 公開日 | 2006-01-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of the Forkhead Domain of FOXP2 Bound to DNA. Structure, 14, 2006
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1XU9
| Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Corticosteroid 11-beta-dehydrogenase, ... | 著者 | Hosfield, D.J, Wu, Y, Skene, R.J, Hilger, M, Jennings, A, Snell, G.P, Aertgeerts, K. | 登録日 | 2004-10-25 | 公開日 | 2004-11-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. J.Biol.Chem., 280, 2005
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4D81
| Metallosphera sedula Vps4 crystal structure | 分子名称: | AAA ATPase, central domain protein, ADENOSINE-5'-DIPHOSPHATE | 著者 | Caillat, C, Macheboeuf, P, Wu, Y, McCarthy, A.A, Boeri-Erba, E, Effantin, G, Gottlinger, H.G, Weissenhorn, W, Renesto, P. | 登録日 | 2014-12-02 | 公開日 | 2015-11-25 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Asymmetric Ring Structure of Vps4 Required for Escrt-III Disassembly. Nat.Commun., 6, 2015
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2B26
| The crystal structure of the protein complex of yeast Hsp40 Sis1 and Hsp70 Ssa1 | 分子名称: | Heat shock 70 kDa protein cognate 2, SIS1 protein | 著者 | Li, J, Wu, Y, Qian, X, Sha, B. | 登録日 | 2005-09-16 | 公開日 | 2006-09-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex. Biochem.J., 398, 2006
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8WSP
| Crystal structure of SFTSV Gn and antibody SF5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab5-H, Ab5-L, ... | 著者 | Chang, Z, Gao, F, Wu, Y. | 登録日 | 2023-10-17 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WSU
| Crystal structure of SFTSV Gc and antibody | 分子名称: | Ab-H, Ab-L, Glycoprotein C | 著者 | Chang, Z, Gao, F, Wu, Y. | 登録日 | 2023-10-17 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WSN
| Crystal structure of SFTSV Gn and antibody SF1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab1-H, ... | 著者 | Chang, Z, Gao, F, Wu, Y. | 登録日 | 2023-10-17 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. Proc.Natl.Acad.Sci.USA, 121, 2024
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7CWF
| Crystal structure of PDE8A catalytic domain in complex with 2c | 分子名称: | 9-[[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]methyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-28 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWG
| Crystal structure of PDE8A catalytic domain in complex with 3a | 分子名称: | 9-[(1~{S})-1-[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]ethyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-28 | 公開日 | 2021-09-01 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWA
| Crystal structure of PDE8A catalytic domain in complex with clofarabine | 分子名称: | 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-27 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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5H94
| Crystal structure of Swine MHC CLASSI for 1.48 angstroms | 分子名称: | Beta-2-microglobulin, MHC class I antigen, Nonapeptide from Influenza A virus HA protein | 著者 | Fan, S, Zhang, N, Wang, S, Wu, Y, Xia, C. | 登録日 | 2015-12-25 | 公開日 | 2016-05-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Structural and Biochemical Analyses of Swine Major Histocompatibility Complex Class I Complexes and Prediction of the Epitope Map of Important Influenza A Virus Strains J.Virol., 90, 2016
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6LXJ
| Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Heavy chain of Z2B3 Fab, ... | 著者 | Jiang, H, Peng, W, Qi, J, Chai, Y, Song, H, Shi, Y, Gao, G.F, Wu, Y. | 登録日 | 2020-02-11 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | 主引用文献 | Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. Mbio, 11, 2020
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6LXI
| Crystal structure of Z2B3 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) | 分子名称: | CALCIUM ION, Heavy chain of Z2B3 Fab, Light chain of Z2B3 Fab, ... | 著者 | Jiang, H, Peng, W, Qi, J, Chai, Y, Song, H, Shi, Y, Gao, G.F, Wu, Y. | 登録日 | 2020-02-11 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. Mbio, 11, 2020
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6LXK
| Crystal structure of Z2B3 D102R Fab in complex with influenza virus neuraminidase from A/Serbia/NS-601/2014 (H1N1) | 分子名称: | CALCIUM ION, Heavy chain of Z2B3-D102R Fab, Light chain of Z2B3-D102R Fab, ... | 著者 | Jiang, H, Peng, W, Qi, J, Chai, Y, Song, H, Shi, Y, Gao, G.F, Wu, Y. | 登録日 | 2020-02-11 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.608 Å) | 主引用文献 | Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. Mbio, 11, 2020
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4K8V
| Structure of cyclic GMP-AMP Synthase (cGAS) | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION | 著者 | Gao, P, Wu, Y, Patel, D.J. | 登録日 | 2013-04-18 | 公開日 | 2013-05-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
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8WKZ
| Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31 | 分子名称: | CALCIUM ION, Melanocortin receptor 4, OLEIC ACID, ... | 著者 | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | 登録日 | 2023-09-28 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67, 2024
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8WKY
| Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25 | 分子名称: | CALCIUM ION, Melanocortin receptor 4, N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, ... | 著者 | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | 登録日 | 2023-09-28 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67, 2024
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5AQB
| DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography | 分子名称: | 3G61_DB15V4, GREEN FLUORESCENT PROTEIN | 著者 | Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A. | 登録日 | 2015-09-21 | 公開日 | 2016-03-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography J.Mol.Biol., 428, 2016
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5AQ7
| DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography | 分子名称: | D12_DB04V3, MALONATE ION | 著者 | Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A. | 登録日 | 2015-09-21 | 公開日 | 2016-03-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography J.Mol.Biol., 428, 2016
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5AQA
| DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography | 分子名称: | OFF7_DB04V3, THIOCYANATE ION | 著者 | Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A. | 登録日 | 2015-09-21 | 公開日 | 2016-03-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography J.Mol.Biol., 428, 2016
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5AAO
| Crystal structure of fluorogen-activating designed ankyrin repeat protein (DARPin) dimer in complex with malachite green | 分子名称: | 4-[[4-(dimethylamino)cyclohexa-2,5-dien-1-ylidene]-(4-methoxyphenyl)methyl]-N,N-dimethyl-aniline, FAD3210 | 著者 | Batyuk, A, Schuetz, M, Kummer, L, Wu, Y, Mittl, P, Plueckthun, A. | 登録日 | 2015-07-27 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools. J. Mol. Biol., 428, 2016
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8U9L
| Crystal Structure of RelA-cRel chimera complex with DNA | 分子名称: | DNA (5'-D(P*GP*AP*AP*TP*CP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*TP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*GP*AP*TP*TP*C)-3'), Transcription factor p65,Proto-oncogene c-Rel chimera | 著者 | Chang, A, Wu, Y, Li, S.X, Smale, S, Chen, L. | 登録日 | 2023-09-19 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (3.091 Å) | 主引用文献 | Crystal Structure of RelA-cRel chimera complex with DNA To Be Published
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6LZZ
| Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a | 分子名称: | 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Huang, Y.Y, Wu, Y, Luo, H.B. | 登録日 | 2020-02-19 | 公開日 | 2021-02-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.40003753 Å) | 主引用文献 | Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors To Be Published
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5AQ9
| DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography | 分子名称: | MALTOSE-BINDING PERIPLASMIC PROTEIN, OFF7_DB08V4 | 著者 | Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A. | 登録日 | 2015-09-21 | 公開日 | 2016-03-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography J.Mol.Biol., 428, 2016
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1TQE
| Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 | 分子名称: | Histone deacetylase 9, MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B | 著者 | Chen, L, Han, A, He, J, Wu, Y, Liu, J.O. | 登録日 | 2004-06-17 | 公開日 | 2004-12-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2. J.Mol.Biol., 345, 2005
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