1A8K
| CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES | 分子名称: | HIV PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide | 著者 | Weber, I.T, Wu, J, Adomat, J, Harrison, R.W, Kimmel, A.R, Wondrak, E.M, Louis, J.M. | 登録日 | 1998-03-27 | 公開日 | 1999-01-13 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates. Eur.J.Biochem., 249, 1997
|
|
3QAM
| Crystal Structure of Glu208Ala mutant of catalytic subunit of cAMP-dependent protein kinase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein kinase inhibitor, ... | 著者 | Yang, J, Wu, J, Steichen, J, Taylor, S.S. | 登録日 | 2011-01-11 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J.Mol.Biol., 415, 2012
|
|
3QAL
| Crystal Structure of Arg280Ala mutant of Catalytic subunit of cAMP-dependent Protein Kinase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein kinase inhibitor, ... | 著者 | Yang, J, Wu, J, Steichen, J, Taylor, S.S. | 登録日 | 2011-01-11 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J.Mol.Biol., 415, 2012
|
|
2MWN
| Talin-F3 / RIAM N-terminal Peptide complex | 分子名称: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Talin-1 | 著者 | Yang, J, Zhu, L, Zhang, H, Hirbawi, J, Fukuda, K, Dwivedi, P, Liu, J, Byzova, T, Plow, E.F, Wu, J, Qin, J. | 登録日 | 2014-11-13 | 公開日 | 2014-12-17 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion. Nat Commun, 5, 2014
|
|
5DOI
| Crystal structure of Tetrahymena p45N and p19 | 分子名称: | Telomerase associated protein p45, Telomerase-associated protein 19 | 著者 | Wan, B, Tang, T, Wu, J, Lei, M. | 登録日 | 2015-09-11 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nat.Struct.Mol.Biol., 22, 2015
|
|
5DOF
| |
5DOK
| Crystal structure of Tetrahymena p45C | 分子名称: | MAGNESIUM ION, Telomerase associated protein p45 | 著者 | Wan, B, Tang, T, Wu, J, Lei, M. | 登録日 | 2015-09-11 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nat.Struct.Mol.Biol., 22, 2015
|
|
8J0O
| cryo-EM structure of human EMC and VDAC | 分子名称: | ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | 著者 | Li, M, Zhang, C, Wu, J, Lei, M. | 登録日 | 2023-04-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural insights into human EMC and its interaction with VDAC. Aging (Albany NY), 16, 2024
|
|
8J0N
| cryo-EM structure of human EMC | 分子名称: | ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | 著者 | Li, M, Zhang, C, Wu, J, Lei, M. | 登録日 | 2023-04-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural insights into human EMC and its interaction with VDAC. Aging (Albany NY), 16, 2024
|
|
1PSU
| Structure of the E. coli PaaI protein from the phyenylacetic acid degradation operon | 分子名称: | Phenylacetic acid degradation protein PaaI | 著者 | Kniewel, R, Buglino, J, Solorzano, V, Wu, J, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2003-06-21 | 公開日 | 2003-07-08 | 最終更新日 | 2021-02-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI. J.Biol.Chem., 281, 2006
|
|
6AH3
| Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate | 分子名称: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, ... | 著者 | Lan, P, Tan, M, Wu, J, Lei, M. | 登録日 | 2018-08-16 | 公開日 | 2018-10-17 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362, 2018
|
|
6AGB
| Cryo-EM structure of yeast Ribonuclease P | 分子名称: | RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, Ribonuclease P protein subunit RPR2, ... | 著者 | Lan, P, Tan, M, Wu, J, Lei, M. | 登録日 | 2018-08-10 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362, 2018
|
|
6BYM
| Crystal structure of the sterol-bound second StART domain of yeast Lam4 | 分子名称: | 25-HYDROXYCHOLESTEROL, Sterol-binding protein | 著者 | Jentsch, J.A, Kiburu, I.N, Wu, J, Pandey, K, Boudker, O, Menon, A.K. | 登録日 | 2017-12-20 | 公開日 | 2018-01-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of sterol binding and transport by a yeast StARkin domain. J. Biol. Chem., 293, 2018
|
|
3OXL
| Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form II) | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION | 著者 | Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. | 登録日 | 2010-09-21 | 公開日 | 2011-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding Nucleic Acids Res., 39, 2011
|
|
6BYD
| Crystal structure of the second StART domain of yeast Lam4 | 分子名称: | Membrane-anchored lipid-binding protein LAM4 | 著者 | Jentsch, J.A, Kiburu, I.N, Wu, J, Pandey, K, Boudker, O, Menon, A.K. | 登録日 | 2017-12-20 | 公開日 | 2018-01-31 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (2.195 Å) | 主引用文献 | Structural basis of sterol binding and transport by a yeast StARkin domain. J. Biol. Chem., 293, 2018
|
|
7JU6
| Structure of RET protein tyrosine kinase in complex with selpercatinib | 分子名称: | FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret, Selpercatinib | 著者 | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | 登録日 | 2020-08-19 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations. Ann Oncol, 32, 2021
|
|
3OXI
| Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of JNK for the Treatment of Neurodegenerative Diseases | 分子名称: | Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 8 interacting protein 1, methyl 3-[(thiophen-2-ylacetyl)amino]thiophene-2-carboxylate | 著者 | Hom, R.K, Bowers, S, Sealy, J, Truong, A, Probst, G.D, Neitzel, M, Neitz, J, Fang, L, Brogley, L, Wu, J, Konradi, A.W, Sham, H, Toth, G, Pan, H, Yao, N, Artis, D.R. | 登録日 | 2010-09-21 | 公開日 | 2011-05-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg.Med.Chem.Lett., 20, 2010
|
|
3OXG
| human lysine methyltransferase Smyd3 in complex with AdoHcy (Form III) | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION | 著者 | Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. | 登録日 | 2010-09-21 | 公開日 | 2011-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
|
|
7JU5
| Structure of RET protein tyrosine kinase in complex with pralsetinib | 分子名称: | FORMIC ACID, Pralsetinib, Proto-oncogene tyrosine-protein kinase receptor Ret | 著者 | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | 登録日 | 2020-08-19 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations. Ann Oncol, 32, 2021
|
|
3OXF
| Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form I) | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION | 著者 | Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. | 登録日 | 2010-09-21 | 公開日 | 2011-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
|
|
7CXR
| |
6L7O
| cryo-EM structure of cyanobacteria Fd-NDH-1L complex | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, BETA-CAROTENE, ... | 著者 | Zhang, C, Shuai, J, Wu, J, Lei, M. | 登録日 | 2019-11-02 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into NDH-1 mediated cyclic electron transfer. Nat Commun, 11, 2020
|
|
6L7P
| cryo-EM structure of cyanobacteria NDH-1LdelV complex | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, BETA-CAROTENE, ... | 著者 | Zhang, C, Shuai, J, Wu, J, Lei, M. | 登録日 | 2019-11-02 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into NDH-1 mediated cyclic electron transfer. Nat Commun, 11, 2020
|
|
7F73
| Cryo-EM structure of human TMEM120B | 分子名称: | MCherry fluorescent protein,Transmembrane protein 120B | 著者 | Ke, M, Wu, J, Yan, Z. | 登録日 | 2021-06-27 | 公開日 | 2021-09-01 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of human TMEM120A and TMEM120B. Cell Discov, 7, 2021
|
|
2I7K
| Solution Structure of the Bromodomain of Human BRD7 Protein | 分子名称: | Bromodomain-containing protein 7 | 著者 | Sun, H, Liu, J, Zhang, J, Huang, H, Wu, J, Shi, Y. | 登録日 | 2006-08-31 | 公開日 | 2007-07-10 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4 Biochem.Biophys.Res.Commun., 358, 2007
|
|