Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7JU5

Structure of RET protein tyrosine kinase in complex with pralsetinib

Summary for 7JU5
Entry DOI10.2210/pdb7ju5/pdb
DescriptorProto-oncogene tyrosine-protein kinase receptor Ret, Pralsetinib, FORMIC ACID, ... (4 entities in total)
Functional Keywordsoncogene, ret, tyrosine kinase, atp-binding, thyroid cancer, non small cell lung cancer, pralsetinib, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight72667.77
Authors
Terzyan, S.S.,Shen, T.,Wu, J.,Mooers, B.H.M. (deposition date: 2020-08-19, release date: 2020-11-11, Last modification date: 2023-10-18)
Primary citationSubbiah, V.,Shen, T.,Terzyan, S.S.,Liu, X.,Hu, X.,Patel, K.P.,Hu, M.,Cabanillas, M.,Behrang, A.,Meric-Bernstam, F.,Vo, P.T.T.,Mooers, B.H.M.,Wu, J.
Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations.
Ann Oncol, 32:261-268, 2021
Cited by
PubMed: 33161056
DOI: 10.1016/j.annonc.2020.10.599
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

219140

PDB entries from 2024-05-01

PDB statisticsPDBj update infoContact PDBjnumon