7V1A
 
 | | Stapled TBS peptide from RIAM bound to talin R7R8 domains | | Descriptor: | 1,2-ETHANEDIOL, ASP-ILE-ASP-GLN-MET-PHE-SER-THR-LEU-LEU-GLY-GLU-MK8-ASP-LEU-LEU-MK8-GLN-SER, Talin-1 | | Authors: | Zhang, P, Gao, T, Wu, J. | | Deposit date: | 2022-05-11 | | Release date: | 2023-06-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.845 Å) | | Cite: | Inhibition of talin-induced integrin activation by a double-hit stapled peptide.
Structure, 31, 2023
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8HPP
 | | Crystal structure of human INTS3 with SAGE1 | | Descriptor: | Integrator complex subunit 3, Sarcoma antigen 1 | | Authors: | Deng, W, Wu, J, Lei, M. | | Deposit date: | 2022-12-12 | | Release date: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Cancer-testis antigen SAGE1 is a pan-cancer master regulator of RNA polymerase II
To Be Published
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5VHP
 | | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... | | Authors: | Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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4ZRU
 | | X-ray crystal structure of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) in complex with 3-[2-[(2S)-pyrrolidin-2-yl]ethynyl]pyridine (TI-5180) | | Descriptor: | 3-[(2S)-pyrrolidin-2-ylethynyl]pyridine, Acetylcholine-binding protein, PHOSPHATE ION | | Authors: | Bobango, J, Sankaran, B, Park, J.F, Wu, J, Talley, T.T. | | Deposit date: | 2015-05-12 | | Release date: | 2015-05-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs, and Structural Features of a High-Affinity, Non-selective NNR Ligand-AChBP Co-crystal Structure
To be Published
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7Y11
 | | Crystal structure of AtSFH5-Sec14 in complex with egg PA | | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, CHLORIDE ION, NICKEL (II) ION, ... | | Authors: | Lu, Y.Q, Wang, X.Q, Luo, Z.P, Wu, J.W. | | Deposit date: | 2022-06-06 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Arabidopsis Sec14 proteins (SFH5 and SFH7) mediate interorganelle transport of phosphatidic acid and regulate chloroplast development.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7Y10
 | | Crystal structure of AtSFH5-Sec14 in complex with DPPA | | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, NICKEL (II) ION, Phosphatidylinositol/phosphatidylcholine transfer protein SFH5 | | Authors: | Lu, Y.Q, Wang, X.Q, Luo, Z.P, Wu, J.W. | | Deposit date: | 2022-06-06 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Arabidopsis Sec14 proteins (SFH5 and SFH7) mediate interorganelle transport of phosphatidic acid and regulate chloroplast development.
Proc.Natl.Acad.Sci.USA, 120, 2023
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4NTT
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4NTS
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7WTC
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state | | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... | | Authors: | Chai, P, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2022-02-04 | | Release date: | 2022-11-09 | | Last modified: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTB
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA | | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Chai, P, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2022-02-04 | | Release date: | 2022-11-09 | | Last modified: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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5X0M
 | | Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, ... | | Authors: | Shen, H, Zhou, Q, Pan, X, Li, Z, Wu, J, Yan, N. | | Deposit date: | 2017-01-21 | | Release date: | 2017-03-08 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.
Science, 355, 2017
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5YYZ
 | | Crystal structure of the MEK1 FHA domain in complex with the HOP1 pThr318 peptide. | | Descriptor: | Meiosis-specific protein HOP1, Meiosis-specific serine/threonine-protein kinase MEK1 | | Authors: | Xie, C, Li, F, Jiang, Y, Wu, J, Shi, Y. | | Deposit date: | 2017-12-11 | | Release date: | 2018-10-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Structural insights into the recognition of phosphorylated Hop1 by Mek1
Acta Crystallogr D Struct Biol, 74, 2018
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5Z1F
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5YWD
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5YYX
 | | Crystal Structure of the MEK1 FHA domain | | Descriptor: | Meiosis-specific serine/threonine-protein kinase MEK1 | | Authors: | Xie, C, Li, F, Jiang, Y, Wu, J, Shi, Y. | | Deposit date: | 2017-12-11 | | Release date: | 2018-10-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.684 Å) | | Cite: | Structural insights into the recognition of phosphorylated Hop1 by Mek1
Acta Crystallogr D Struct Biol, 74, 2018
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5YW7
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8TK2
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid | | Descriptor: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3, ... | | Authors: | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | | Deposit date: | 2023-07-25 | | Release date: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) binding 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid
To Be Published
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7WTD
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ... | | Authors: | Chai, P, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2022-02-04 | | Release date: | 2022-11-09 | | Last modified: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTE
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2 | | Descriptor: | ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ... | | Authors: | Chai, P, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2022-02-04 | | Release date: | 2022-11-09 | | Last modified: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTA
 | | Cryo-EM structure of human pyruvate carboxylase in apo state | | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial | | Authors: | Chai, P, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2022-02-04 | | Release date: | 2022-11-09 | | Last modified: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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2QZQ
 | | Crystal structure of C-terminal of Aida | | Descriptor: | Axin interactor, dorsalization associated protein | | Authors: | Zheng, L.S, Wu, J.W. | | Deposit date: | 2007-08-17 | | Release date: | 2008-09-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of C-terminal of Aida
To be Published
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7VIO
 | | Crystal structure of recombinant horse spleen apo-R168H/L169C-Fr | | Descriptor: | CADMIUM ION, Ferritin light chain, GLYCEROL, ... | | Authors: | Lu, C, Peng, X, Maity, B, Ito, N, Abe, S, Wu, J, Ueno, T, Lu, D. | | Deposit date: | 2021-09-27 | | Release date: | 2022-06-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Design of a gold clustering site in an engineered apo-ferritin cage.
Commun Chem, 5, 2022
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