7WTD

Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1

Summary for 7WTD

• Entry DOI: 10.2210/pdb7wtd/pdb
• Related: 7WTA
• EMDB information: 32779
• Descriptor: Pyruvate carboxylase, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, COENZYME A (3 entities in total)
• Functional Keywords: pyruvate carboxylase, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 521746.87

Authors

Chai, P.,Lan, P.,Wu, J.,Lei, M. (deposition date: 2022-02-04, release date: 2022-11-09, Last modification date: 2022-11-16)

• Primary citation: Chai, P.,Lan, P.,Li, S.,Yao, D.,Chang, C.,Cao, M.,Shen, Y.,Ge, S.,Wu, J.,Lei, M.,Fan, X.; Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.; Mol.Cell, 82:4116-4130.e6, 2022; PubMed: 36283412; DOI: 10.1016/j.molcel.2022.09.033

Experimental method

ELECTRON MICROSCOPY (3.9 Å)