7WTB

Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA

Summary for 7WTB

• Entry DOI: 10.2210/pdb7wtb/pdb
• Related: 7WTA
• EMDB information: 32775
• Descriptor: Pyruvate carboxylase, mitochondrial, 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: pyruvate carboxylase, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 522742.21

Authors

Chai, P.,Lan, P.,Wu, J.,Lei, M. (deposition date: 2022-02-04, release date: 2022-11-09, Last modification date: 2022-11-16)

• Primary citation: Chai, P.,Lan, P.,Li, S.,Yao, D.,Chang, C.,Cao, M.,Shen, Y.,Ge, S.,Wu, J.,Lei, M.,Fan, X.; Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.; Mol.Cell, 82:4116-4130.e6, 2022; PubMed: 36283412; DOI: 10.1016/j.molcel.2022.09.033

Experimental method

ELECTRON MICROSCOPY (3.7 Å)