7PG5
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![BU of 7pg5 by Molmil](/molmil-images/mine/7pg5) | Crystal Structure of PI3Kalpha | 分子名称: | GLYCEROL, PHOSPHATE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | 登録日 | 2021-08-13 | 公開日 | 2022-08-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.20029068 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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7PG6
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![BU of 7pg6 by Molmil](/molmil-images/mine/7pg6) | Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | 登録日 | 2021-08-13 | 公開日 | 2022-08-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.49943733 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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7OWG
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![BU of 7owg by Molmil](/molmil-images/mine/7owg) | human DEPTOR in a complex with mutant human mTORC1 A1459P | 分子名称: | DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... | 著者 | Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
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3ENE
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![BU of 3ene by Molmil](/molmil-images/mine/3ene) | Complex of PI3K gamma with an inhibitor | 分子名称: | 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Apsel, B, Blair, J.A, Gonzalez, B.Z, Nazif, T.M, Feldman, M.E, Williams, R.L, Shokat, K.M, Knight, Z.A. | 登録日 | 2008-09-25 | 公開日 | 2008-10-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases Nat.Chem.Biol., 4, 2008
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6SB2
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![BU of 6sb2 by Molmil](/molmil-images/mine/6sb2) | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | 著者 | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | 登録日 | 2019-07-18 | 公開日 | 2019-10-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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6SB0
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![BU of 6sb0 by Molmil](/molmil-images/mine/6sb0) | cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | 著者 | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | 登録日 | 2019-07-18 | 公開日 | 2019-10-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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5NP0
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![BU of 5np0 by Molmil](/molmil-images/mine/5np0) | Closed dimer of human ATM (Ataxia telangiectasia mutated) | 分子名称: | Serine-protein kinase ATM | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | 登録日 | 2017-04-13 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
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5NP1
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![BU of 5np1 by Molmil](/molmil-images/mine/5np1) | Open protomer of human ATM (Ataxia telangiectasia mutated) | 分子名称: | Serine-protein kinase ATM | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | 登録日 | 2017-04-13 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
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6S6A
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![BU of 6s6a by Molmil](/molmil-images/mine/6s6a) | Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L. | 登録日 | 2019-07-02 | 公開日 | 2019-10-16 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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5JHB
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![BU of 5jhb by Molmil](/molmil-images/mine/5jhb) | Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin3 | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol | 著者 | Burke, J.E, Inglis, A.J, Williams, R.L. | 登録日 | 2016-04-20 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8, 2017
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5KC2
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![BU of 5kc2 by Molmil](/molmil-images/mine/5kc2) | Negative stain structure of Vps15/Vps34 complex | 分子名称: | Phosphatidylinositol 3-kinase VPS34, Serine/threonine-protein kinase VPS15 | 著者 | Kirsten, M.L, Zhang, L, Ohashi, Y, Perisic, O, Williams, R.L, Sachse, C. | 登録日 | 2016-06-04 | 公開日 | 2016-10-05 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (28 Å) | 主引用文献 | Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Autophagy, 12, 2016
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5JHA
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![BU of 5jha by Molmil](/molmil-images/mine/5jha) | Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin2 | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol | 著者 | Burke, J.E, Inglis, A.J, Williams, R.L. | 登録日 | 2016-04-20 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8, 2017
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7BL1
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![BU of 7bl1 by Molmil](/molmil-images/mine/7bl1) | human complex II-BATS bound to membrane-attached Rab5a-GTP | 分子名称: | Beclin-1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Tremel, S, Morado, D.R, Kovtun, O, Williams, R.L, Briggs, J.A.G, Munro, S, Ohashi, Y, Bertram, J, Perisic, O. | 登録日 | 2021-01-17 | 公開日 | 2021-03-03 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | 主引用文献 | Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. Nat Commun, 12, 2021
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5FVM
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![BU of 5fvm by Molmil](/molmil-images/mine/5fvm) | Cryo electron microscopy of a complex of Tor and Lst8 | 分子名称: | SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 | 著者 | Baretic, D, Berndt, A, Ohashi, Y, Johnson, C.M, Williams, R.L. | 登録日 | 2016-02-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | 主引用文献 | Tor Forms a Dimer Through an N-Terminal Helical Solenoid with a Complex Topology Nat.Commun., 7, 2016
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2DOQ
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![BU of 2doq by Molmil](/molmil-images/mine/2doq) | crystal structure of Sfi1p/Cdc31p complex | 分子名称: | CALCIUM ION, Cell division control protein 31, SFI1p | 著者 | Li, S, Sandercock, A.M, Conduit, P.T, Robinson, C.V, Williams, R.L, Kilmartin, J.V. | 登録日 | 2006-05-03 | 公開日 | 2006-06-27 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. J.Cell Biol., 173, 2006
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1RLW
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![BU of 1rlw by Molmil](/molmil-images/mine/1rlw) | |
2BH8
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![BU of 2bh8 by Molmil](/molmil-images/mine/2bh8) | Combinatorial Protein 1b11 | 分子名称: | 1B11 | 著者 | De Bono, S, Riechmann, L, Girard, E, Williams, R.L, Winter, G. | 登録日 | 2005-01-07 | 公開日 | 2005-02-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Segment of Cold Shock Protein Directs the Folding of a Combinatorial Protein Proc.Natl.Acad.Sci.USA, 102, 2005
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2CAY
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![BU of 2cay by Molmil](/molmil-images/mine/2cay) | Vps36 N-terminal PH domain | 分子名称: | SULFATE ION, VACUOLAR PROTEIN SORTING PROTEIN 36 | 著者 | Teo, H, Williams, R.L, Perisic, O, Gill, D.J. | 登録日 | 2005-12-23 | 公開日 | 2006-04-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes. Cell(Cambridge,Mass.), 125, 2006
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1UZX
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![BU of 1uzx by Molmil](/molmil-images/mine/1uzx) | A complex of the Vps23 UEV with ubiquitin | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, UBIQUITIN, ... | 著者 | Teo, H, Williams, R.L. | 登録日 | 2004-03-18 | 公開日 | 2004-03-30 | 最終更新日 | 2017-07-05 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural Insights Into Endosomal Sorting Complex Required for Transport (Escrt-I) Recognition of Ubiquitinated Proteins J.Biol.Chem., 279, 2004
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1TLG
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![BU of 1tlg by Molmil](/molmil-images/mine/1tlg) | STRUCTURE OF A TUNICATE C-TYPE LECTIN COMPLEXED WITH D-GALACTOSE | 分子名称: | CALCIUM ION, POLYANDROCARPA LECTIN, ZINC ION, ... | 著者 | Poget, S.F, Legge, G.B, Bycroft, M, Williams, R.L. | 登録日 | 1998-10-16 | 公開日 | 1999-07-23 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose. J.Mol.Biol., 290, 1999
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2CAZ
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![BU of 2caz by Molmil](/molmil-images/mine/2caz) | ESCRT-I core | 分子名称: | PROTEIN SRN2, SUPPRESSOR PROTEIN STP22 OF TEMPERATURE-SENSITIVE ALPHA-FACTOR RECEPTOR AND ARGININE PERMEASE, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS28 | 著者 | Gill, D.J, Teo, H, Sun, J, Perisic, O, Veprintsev, D.B, Vallis, Y, Emr, S.D, Williams, R.L. | 登録日 | 2005-12-23 | 公開日 | 2006-04-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes. Cell(Cambridge,Mass.), 125, 2006
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1UPT
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![BU of 1upt by Molmil](/molmil-images/mine/1upt) | Structure of a complex of the golgin-245 GRIP domain with Arl1 | 分子名称: | ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1, GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A MEMBER 4, ... | 著者 | Panic, B, Perisic, O, Veprintsev, D.B, Williams, R.L, Munro, S. | 登録日 | 2003-10-12 | 公開日 | 2003-10-30 | 最終更新日 | 2019-10-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis for Arl1-Dependent Targeting of Homodimeric Grip Domains to the Golgi Apparatus Mol.Cell, 12, 2003
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1W2D
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![BU of 1w2d by Molmil](/molmil-images/mine/1w2d) | Human Inositol (1,4,5)-trisphosphate 3-kinase complexed with Mn2+/ADP/Ins(1,3,4,5)P4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, INOSITOL-TRISPHOSPHATE 3-KINASE A, ... | 著者 | Gonzalez, B, Schell, M.J, Irvine, R.F, Williams, R.L. | 登録日 | 2004-07-01 | 公開日 | 2004-09-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase Mol.Cell, 15, 2004
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1W2F
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![BU of 1w2f by Molmil](/molmil-images/mine/1w2f) | Human Inositol (1,4,5)-trisphosphate 3-kinase substituted with selenomethionine | 分子名称: | INOSITOL-TRISPHOSPHATE 3-KINASE A, SULFATE ION | 著者 | Gonzalez, B, Schell, M.J, Irvine, R.F, Williams, R.L. | 登録日 | 2004-07-01 | 公開日 | 2004-09-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase Mol.Cell, 15, 2004
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5DFZ
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![BU of 5dfz by Molmil](/molmil-images/mine/5dfz) | Structure of Vps34 complex II from S. cerevisiae. | 分子名称: | Nanobody binding S. cerevisiae Vps34, Phosphatidylinositol 3-kinase VPS34, Putative N-terminal domain of S. cerevisiae Vps30, ... | 著者 | Rostislavleva, K, Soler, N, Ohashi, Y, Zhang, L, Williams, R.L. | 登録日 | 2015-08-27 | 公開日 | 2015-10-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science, 350, 2015
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