3ENE
Complex of PI3K gamma with an inhibitor
Summary for 3ENE
Entry DOI | 10.2210/pdb3ene/pdb |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | lipid kinase, phosphoinositide, inhibitor, 3-kinase, signaling, pyrazolopyrimidine, pik-208, s2, kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 110071.37 |
Authors | Apsel, B.,Blair, J.A.,Gonzalez, B.Z.,Nazif, T.M.,Feldman, M.E.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. (deposition date: 2008-09-25, release date: 2008-10-14, Last modification date: 2023-11-01) |
Primary citation | Apsel, B.,Blair, J.A.,Gonzalez, B.,Nazif, T.M.,Feldman, M.E.,Aizenstein, B.,Hoffman, R.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases Nat.Chem.Biol., 4:691-699, 2008 Cited by PubMed: 18849971DOI: 10.1038/nchembio.117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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