8VZ6
 
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8GH6
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8B1U
 | | RecBCD-DNA in complex with the phage protein Abc2 and host PpiB | | Descriptor: | Anti-RecBCD protein 2, DNA (70-MER), MAGNESIUM ION, ... | | Authors: | Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. | | Deposit date: | 2022-09-12 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub.
Elife, 11, 2022
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8B1R
 | | RecBCD in complex with the phage protein gp5.9 | | Descriptor: | MAGNESIUM ION, Probable RecBCD inhibitor gp5.9, RecBCD enzyme subunit RecB, ... | | Authors: | Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. | | Deposit date: | 2022-09-12 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub.
Elife, 11, 2022
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8B1T
 | | RecBCD-DNA in complex with the phage protein Abc2 | | Descriptor: | Anti-RecBCD protein 2, DNA (70-MER), MAGNESIUM ION, ... | | Authors: | Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. | | Deposit date: | 2022-09-12 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub.
Elife, 11, 2022
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7B9V
 | | Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound | | Descriptor: | 5' exon of UBC4 mRNA, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0054360.mRNA.1.CDS.1, ... | | Authors: | Wilkinson, M.E, Fica, S.M, Galej, W.P, Nagai, K. | | Deposit date: | 2020-12-14 | | Release date: | 2021-03-10 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis for conformational equilibrium of the catalytic spliceosome.
Mol.Cell, 81, 2021
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8W35
 | | Aca2 from Pectobacterium phage ZF40 bound to RNA | | Descriptor: | Anti-CRISPR associated (Aca) protein, Aca2, IR2 and IR-RBS RNA | | Authors: | Wilkinson, M.E, Birkholz, N, Kimanius, D, Fineran, P.C. | | Deposit date: | 2024-02-21 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein.
Nature, 631, 2024
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9MTY
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8UYO
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9GZS
 | | WT-IAPP cryo-EM structure Type LLU - control reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 2025
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9GZX
 | | WT-IAPP cryo-EM structure Type LLU, doxazosin reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 2025
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9GZT
 | | WT-IAPP cryo-EM structure Type LLUU - control reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 2025
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9GZY
 | | WT-IAPP cryo-EM structure Type LLUU, doxazosin reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 2025
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6EXN
 | | Post-catalytic P complex spliceosome with 3' splice site docked | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ... | | Authors: | Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K. | | Deposit date: | 2017-11-08 | | Release date: | 2018-01-17 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Science, 358, 2017
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9GZP
 | | WT-IAPP cryo-EM structure Type LL - control reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 2025
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9GZW
 | | WT-IAPP cryo-EM structure Type LL, doxazosin reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 2025
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9GZ6
 | | WT-IAPP cryo-EM structure Type SS - control reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-03 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 2025
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8BFB
 | | Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice) | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | | Deposit date: | 2022-10-24 | | Release date: | 2023-05-31 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
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8BFA
 | | Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | | Deposit date: | 2022-10-24 | | Release date: | 2023-05-31 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
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8DGF
 | | Avs4 bound to phage PhiV-1 portal | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding protein Avs4, MAGNESIUM ION, ... | | Authors: | Wilkinson, M.E, Gao, L, Strecker, J, Makarova, K.S, Macrae, R.K, Koonin, E.V, Zhang, F. | | Deposit date: | 2022-06-23 | | Release date: | 2022-08-03 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Prokaryotic innate immunity through pattern recognition of conserved viral proteins.
Science, 377, 2022
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8DGC
 | | Avs3 bound to phage PhiV-1 terminase | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SeAvs3, ... | | Authors: | Wilkinson, M.E, Gao, L, Strecker, J, Makarova, K.S, Macrae, R.K, Koonin, E.V, Zhang, F. | | Deposit date: | 2022-06-23 | | Release date: | 2022-08-03 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Prokaryotic innate immunity through pattern recognition of conserved viral proteins.
Science, 377, 2022
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9DTR
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8OHI
 | | Structure of the Fmoc-Tau-PAM4 Type 2 amyloid fibril | | Descriptor: | Microtubule-associated protein tau | | Authors: | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | | Deposit date: | 2023-03-21 | | Release date: | 2024-02-21 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Local structural preferences in shaping tau amyloid polymorphism.
Nat Commun, 15, 2024
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8OH2
 | | Structure of the Tau-PAM4 Type 1 amyloid fibril | | Descriptor: | Microtubule-associated protein tau | | Authors: | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | | Deposit date: | 2023-03-20 | | Release date: | 2024-02-21 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Local structural preferences in shaping tau amyloid polymorphism.
Nat Commun, 15, 2024
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8OHP
 | | Structure of the Fmoc-Tau-PAM4 Type 3 amyloid fibril | | Descriptor: | Microtubule-associated protein tau | | Authors: | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | | Deposit date: | 2023-03-21 | | Release date: | 2024-02-21 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Local structural preferences in shaping tau amyloid polymorphism.
Nat Commun, 15, 2024
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