1F4K
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![BU of 1f4k by Molmil](/molmil-images/mine/1f4k) | CRYSTAL STRUCTURE OF THE REPLICATION TERMINATOR PROTEIN/B-SITE DNA COMPLEX | 分子名称: | 5'-D(*CP*TP*AP*TP*GP*AP*AP*CP*AP*TP*AP*AP*TP*GP*TP*TP*CP*AP*TP*AP*G)-3', 5'-D(*CP*TP*AP*TP*GP*AP*AP*CP*AP*TP*TP*AP*TP*GP*TP*TP*CP*AP*TP*AP*G)-3', REPLICATION TERMINATION PROTEIN | 著者 | Wilce, J.A, Vivian, J.P, Hastings, A.F, Otting, G, Folmer, R.H.A, Duggin, I.G, Wake, R.G, Wilce, M.C.J. | 登録日 | 2000-06-08 | 公開日 | 2001-06-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest Nat.Struct.Biol., 8, 2001
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3PQZ
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![BU of 3pqz by Molmil](/molmil-images/mine/3pqz) | Grb7 SH2 with peptide | 分子名称: | Growth factor receptor-bound protein 7, cyclic peptide | 著者 | Wilce, J.A. | 登録日 | 2010-11-29 | 公開日 | 2011-07-20 | 最終更新日 | 2011-09-21 | 実験手法 | X-RAY DIFFRACTION (2.413 Å) | 主引用文献 | Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
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5D0J
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![BU of 5d0j by Molmil](/molmil-images/mine/5d0j) | Grb7 SH2 with inhibitor peptide | 分子名称: | G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION | 著者 | Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. | 登録日 | 2015-08-03 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
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7MP3
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![BU of 7mp3 by Molmil](/molmil-images/mine/7mp3) | |
5ITH
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![BU of 5ith by Molmil](/molmil-images/mine/5ith) | |
5EEL
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![BU of 5eel by Molmil](/molmil-images/mine/5eel) | Grb7 SH2 with bicyclic peptide inhibitor | 分子名称: | Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... | 著者 | Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. | 登録日 | 2015-10-23 | 公開日 | 2016-06-15 | 最終更新日 | 2018-12-26 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
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4WWQ
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![BU of 4wwq by Molmil](/molmil-images/mine/4wwq) | Apo structure of the Grb7 SH2 domain | 分子名称: | Growth factor receptor-bound protein 7, MALONIC ACID | 著者 | Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. | 登録日 | 2014-11-12 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
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4X6S
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![BU of 4x6s by Molmil](/molmil-images/mine/4x6s) | Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide | 分子名称: | Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 | 著者 | Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. | 登録日 | 2014-12-09 | 公開日 | 2015-09-23 | 最終更新日 | 2015-10-28 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
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1ZTG
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![BU of 1ztg by Molmil](/molmil-images/mine/1ztg) | human alpha polyC binding protein KH1 | 分子名称: | 5'-D(P*CP*CP*CP*TP*CP*CP*CP*T)-3', POLY(RC)-BINDING PROTEIN 1 | 著者 | Sidiqi, M, Wilce, J.A, Barker, A, Schmidgerger, J, Leedman, P.J, Wilce, M.C.J. | 登録日 | 2005-05-27 | 公開日 | 2006-05-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides Nucleic Acids Res., 40, 2012
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5TYI
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![BU of 5tyi by Molmil](/molmil-images/mine/5tyi) | Grb7 SH2 with bicyclic peptide containing pY mimetic | 分子名称: | Growth factor receptor-bound protein 7, Peptide inhibitor | 著者 | Watson, G.M, Wilce, M.C.J, Wilce, J.A. | 登録日 | 2016-11-20 | 公開日 | 2017-11-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
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5U1Q
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![BU of 5u1q by Molmil](/molmil-images/mine/5u1q) | Grb7-SH2 with bicyclic peptide inhibitor | 分子名称: | CHLORIDE ION, Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST | 著者 | Watson, G.M, Wilce, M.C.J, Wilce, J.A. | 登録日 | 2016-11-28 | 公開日 | 2017-11-15 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
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2QMS
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2EFW
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![BU of 2efw by Molmil](/molmil-images/mine/2efw) | Crystal structure of the RTP:nRB complex from Bacillus subtilis | 分子名称: | DNA (5'-D(*DCP*DT*DAP*DTP*DGP*DTP*DAP*DCP*DCP*DAP*DAP*DAP*DTP*DGP*DTP*DTP*DCP*DAP*DGP*DTP*DC)-3'), DNA (5'-D(*DGP*DAP*DCP*DTP*DGP*DAP*DAP*DCP*DAP*DTP*DTP*DTP*DGP*DGP*DTP*DAP*DCP*DAP*DTP*DAP*DG)-3'), Replication termination protein | 著者 | Vivian, J.P, Porter, C.J, Wilce, J.A, Wilce, M.C.J. | 登録日 | 2007-02-26 | 公開日 | 2008-02-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | An asymmetric structure of the Bacillus subtilis replication terminator protein in complex with DNA J.Mol.Biol., 370, 2007
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4J1Y
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![BU of 4j1y by Molmil](/molmil-images/mine/4j1y) | The X-ray crystal structure of human complement protease C1s zymogen | 分子名称: | Complement C1s subcomponent | 著者 | Perry, A.J, Wijeyewickrema, L.C, Wilmann, P.G, Gunzburg, M.J, D'Andrea, L, Irving, J.A, Pang, S.S, Duncan, R.C, Wilce, J.A, Whisstock, J.C, Pike, R.N. | 登録日 | 2013-02-03 | 公開日 | 2013-04-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6645 Å) | 主引用文献 | A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4. J.Biol.Chem., 288, 2013
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2DPU
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![BU of 2dpu by Molmil](/molmil-images/mine/2dpu) | |
2DPD
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![BU of 2dpd by Molmil](/molmil-images/mine/2dpd) | |
2DQR
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![BU of 2dqr by Molmil](/molmil-images/mine/2dqr) | |
8SUC
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![BU of 8suc by Molmil](/molmil-images/mine/8suc) | NHL-2 NHL domain | 分子名称: | MAGNESIUM ION, NHL (Ring finger b-box coiled coil) domain containing protein | 著者 | Colson, R.N, Wilce, J.A. | 登録日 | 2023-05-12 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | NHL-2 NHL domain To Be Published
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1WVN
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![BU of 1wvn by Molmil](/molmil-images/mine/1wvn) | |
5U06
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![BU of 5u06 by Molmil](/molmil-images/mine/5u06) | Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic | 分子名称: | Growth factor receptor-bound protein 7, POTASSIUM ION, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST | 著者 | Watson, G.M, Wilce, J.A. | 登録日 | 2016-11-22 | 公開日 | 2017-11-15 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
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3VKE
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![BU of 3vke by Molmil](/molmil-images/mine/3vke) | |
1J0R
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![BU of 1j0r by Molmil](/molmil-images/mine/1j0r) | Crystal structure of the replication termination protein mutant C110S | 分子名称: | replication termination protein | 著者 | Vivian, J.P, Hastings, A.F, Duggin, I.G, Wake, R.G, Wilce, M.C.J, Wilce, J.A. | 登録日 | 2002-11-20 | 公開日 | 2003-11-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The impact of single cysteine residue mutations on the replication terminator protein Biochem.Biophys.Res.Commun., 310, 2003
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1WO3
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![BU of 1wo3 by Molmil](/molmil-images/mine/1wo3) | Solution structure of Minimal Mutant 1 (MM1): Multiple alanine mutant of non-native CHANCE domain | 分子名称: | CREB Binding Protein, ZINC ION | 著者 | Sharpe, B.K, Liew, C.K, Wilce, J.A, Crossley, M, Matthews, J.M, Mackay, J.P. | 登録日 | 2004-08-12 | 公開日 | 2005-03-08 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting Structure, 13, 2005
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1WO6
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![BU of 1wo6 by Molmil](/molmil-images/mine/1wo6) | Solution structure of Designed Functional Finger 5 (DFF5): Designed mutant based on non-native CHANCE domain | 分子名称: | CREB Binding Protein, ZINC ION | 著者 | Sharpe, B.K, Liew, C.K, Wilce, J.A, Crossley, M, Matthews, J.M, Mackay, J.P. | 登録日 | 2004-08-12 | 公開日 | 2005-03-08 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting Structure, 13, 2005
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1WO4
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![BU of 1wo4 by Molmil](/molmil-images/mine/1wo4) | Solution structure of Minimal Mutant 2 (MM2): Multiple alanine mutant of non-native CHANCE domain | 分子名称: | CREB Binding Protein, ZINC ION | 著者 | Sharpe, B.K, Liew, C.K, Wilce, J.A, Crossley, M, Matthews, J.M, Mackay, J.P. | 登録日 | 2004-08-12 | 公開日 | 2005-03-08 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting Structure, 13, 2005
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