8QZX
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![BU of 8qzx by Molmil](/molmil-images/mine/8qzx) | |
8A0G
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![BU of 8a0g by Molmil](/molmil-images/mine/8a0g) | Human deoxyhypusine synthase with trapped transition state | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,3-DIAMINOPROPANE, Deoxyhypusine synthase, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2022-05-27 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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8A0E
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![BU of 8a0e by Molmil](/molmil-images/mine/8a0e) | CryoEM structure of DHS-eIF5A1 complex | Descriptor: | Deoxyhypusine synthase, Eukaryotic translation initiation factor 5A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Wator, E, Wilk, P, Biela, A.P, Rawski, M, Grudnik, P. | Deposit date: | 2022-05-27 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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8A0F
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![BU of 8a0f by Molmil](/molmil-images/mine/8a0f) | Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, Deoxyhypusine synthase, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2022-05-27 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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8QZW
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![BU of 8qzw by Molmil](/molmil-images/mine/8qzw) | |
8QZV
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![BU of 8qzv by Molmil](/molmil-images/mine/8qzv) | |
7A6S
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![BU of 7a6s by Molmil](/molmil-images/mine/7a6s) | Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Deoxyhypusine synthase, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-08-26 | Release date: | 2022-03-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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7A6T
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![BU of 7a6t by Molmil](/molmil-images/mine/7a6t) | Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase in complex with NAD and spermidine | Descriptor: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Deoxyhypusine synthase, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-08-26 | Release date: | 2022-03-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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6XXK
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![BU of 6xxk by Molmil](/molmil-images/mine/6xxk) | Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXM
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![BU of 6xxm by Molmil](/molmil-images/mine/6xxm) | Crystal Structure of Human Deoxyhypusine Synthase in complex with putrescine | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,4-DIAMINOBUTANE, Deoxyhypusine synthase | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXJ
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![BU of 6xxj by Molmil](/molmil-images/mine/6xxj) | Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine and NAD | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXH
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![BU of 6xxh by Molmil](/molmil-images/mine/6xxh) | Crystal Structure of Human Deoxyhypusine Synthase in apo form | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXL
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![BU of 6xxl by Molmil](/molmil-images/mine/6xxl) | Crystal Structure of Human Deoxyhypusine Synthase in complex with spermine | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXI
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![BU of 6xxi by Molmil](/molmil-images/mine/6xxi) | Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.679 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6SRF
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![BU of 6srf by Molmil](/molmil-images/mine/6srf) | |
6SRE
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![BU of 6sre by Molmil](/molmil-images/mine/6sre) | Crystal Structure of Human Prolidase S202F variant expressed in the presence of chaperones | Descriptor: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | Authors: | Wator, E, Rutkiewicz, M, Wilk, P. | Deposit date: | 2019-09-05 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Co-expression with chaperones can affect protein 3D structure as exemplified by loss-of-function variants of human prolidase. Febs Lett., 594, 2020
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6SRG
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![BU of 6srg by Molmil](/molmil-images/mine/6srg) | |
6ZQ5
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![BU of 6zq5 by Molmil](/molmil-images/mine/6zq5) | Crystal structure of Chaetomium thermophilum Glycerol Kinase in P2221 space group | Descriptor: | 1,2-ETHANEDIOL, Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Malecki, P, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6ZQ4
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![BU of 6zq4 by Molmil](/molmil-images/mine/6zq4) | |
6ZQ6
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![BU of 6zq6 by Molmil](/molmil-images/mine/6zq6) | |
6ZQ7
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![BU of 6zq7 by Molmil](/molmil-images/mine/6zq7) | Crystal structure of Chaetomium thermophilum Glycerol Kinase in I222 space group | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.421 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6ZQ8
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![BU of 6zq8 by Molmil](/molmil-images/mine/6zq8) | Crystal structure of Chaetomium thermophilum Glycerol Kinase in P3221 space group | Descriptor: | Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Malecki, P, Tokarz, P, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6QSC
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![BU of 6qsc by Molmil](/molmil-images/mine/6qsc) | Crystal Structure of Arg470His mutant of Human Prolidase with Mn ions and GlyPro ligand | Descriptor: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | Authors: | Wilk, P, Wator, E, Weiss, M.S. | Deposit date: | 2019-02-20 | Release date: | 2020-03-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.569 Å) | Cite: | Structural analysis of new compound heterozygous variants in PEPD gene identified in a patient with Prolidase Deficiency diagnosed by exome sequencing. Genet Mol Biol, 44, 2021
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6QSB
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6R2N
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![BU of 6r2n by Molmil](/molmil-images/mine/6r2n) | Crystal structure of KlGlk1 glucokinase from Kluyveromyces lactis | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, Glucokinase-1 | Authors: | Zak, K, Wator, E, Grudnik, P. | Deposit date: | 2019-03-18 | Release date: | 2019-10-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.596 Å) | Cite: | Crystal Structure of Kluyveromyces lactis Glucokinase ( Kl Glk1). Int J Mol Sci, 20, 2019
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