8A0F

Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD

Summary for 8A0F

• Entry DOI: 10.2210/pdb8a0f/pdb
• Related: 6XXJ 7A6S 7A6T 8A0E
• Descriptor: Deoxyhypusine synthase, SPERMIDINE, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: hypusination, transferase, posttranslational modification
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 84122.77

Authors

Wator, E.,Wilk, P.,Grudnik, P. (deposition date: 2022-05-27, release date: 2023-04-05, Last modification date: 2024-02-07)

• Primary citation: Wator, E.,Wilk, P.,Biela, A.,Rawski, M.,Zak, K.M.,Steinchen, W.,Bange, G.,Glatt, S.,Grudnik, P.; Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.; Nat Commun, 14:1698-1698, 2023; PubMed: 36973244; DOI: 10.1038/s41467-023-37305-2

Experimental method

X-RAY DIFFRACTION (1.64 Å)