8A0F
Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Deoxyhypusine synthase | polymer | 371 | 41162.6 | 2 | UniProt (P49366) Pfam (PF01916) In PDB | Homo sapiens (human) | DHS |
2 | A, B | SPERMIDINE | non-polymer | 145.2 | 2 | Chemie (SPD) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | A, B | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
5 | B | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 1 | Chemie (MRD) | |||
6 | water | water | 18.0 | 443 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 369 (UniProt: P49366)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 329 | Lys 329 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 82325.2 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1797.6 | |
All* | Total formula weight | 84122.8 |