8A0F
Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Deoxyhypusine synthase | polymer | 371 | 41162.6 | 2 | UniProt (P49366) Pfam (PF01916) | Homo sapiens (human) | DHS |
| 2 | C, F (A, B) | SPERMIDINE | non-polymer | 145.2 | 2 | Chemie (SPD) | |||
| 3 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | E, H (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 5 | G (B) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 1 | Chemie (MRD) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 443 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 369 (UniProt: P49366)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 329 | Lys 329 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82325.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1797.6 | |
| All* | Total formula weight | 84122.8 |
