8A0E

CryoEM structure of DHS-eIF5A1 complex

Summary for 8A0E

• Entry DOI: 10.2210/pdb8a0e/pdb
• Related: 6XXJ 7A6S 7A6T
• EMDB information: 15052
• Descriptor: Deoxyhypusine synthase, Eukaryotic translation initiation factor 5A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: hypusination, transferase, posttranslational modification
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 184545.81

Authors

Wator, E.,Wilk, P.,Biela, A.P.,Rawski, M.,Grudnik, P. (deposition date: 2022-05-27, release date: 2023-04-05)

• Primary citation: Wator, E.,Wilk, P.,Biela, A.,Rawski, M.,Zak, K.M.,Steinchen, W.,Bange, G.,Glatt, S.,Grudnik, P.; Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.; Nat Commun, 14:1698-1698, 2023; PubMed: 36973244; DOI: 10.1038/s41467-023-37305-2

Experimental method

ELECTRON MICROSCOPY (2.8 Å)