8A0E
CryoEM structure of DHS-eIF5A1 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Deoxyhypusine synthase | polymer | 371 | 41098.5 | 2 | UniProt (P49366) Pfam (PF01916) In PDB | Homo sapiens (human) | DHS |
2 | C, D | Deoxyhypusine synthase | polymer | 371 | 41130.5 | 2 | UniProt (P49366) Pfam (PF01916) In PDB | Homo sapiens (human) | DHS |
3 | E | Eukaryotic translation initiation factor 5A | polymer | 156 | 16998.4 | 1 | UniProt (A0A2Y9EFS4) Pfam (PF21485) Pfam (PF01287) UniProt (by SIFTS) (P63241) In PDB | Homo sapiens (human) | eIF-5A |
4 | A, B, C, D | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
5 | A, B, D | SPERMIDINE | non-polymer | 145.2 | 3 | Chemie (SPD) |
Sequence modifications
A, B: 1 - 369 (UniProt: P49366)
C, D: 1 - 369 (UniProt: P49366)
E: 1 - 154 (UniProt: A0A2Y9EFS4)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 329 | Lys 329 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 329 | Lys 329 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 181456.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 3089.4 | |
All* | Total formula weight | 184545.8 |