6MLM
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![BU of 6mlm by Molmil](/molmil-images/mine/6mlm) | H7 HA0 in complex with Fv from H7.5 IgG | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain Fv of H7.5 Fab, Hemagglutinin HA1 chain, ... | Authors: | Pallesen, J, Turner, H.L, Ward, A.B. | Deposit date: | 2018-09-27 | Release date: | 2019-02-20 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains. PLoS Biol., 17, 2019
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4NCO
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![BU of 4nco by Molmil](/molmil-images/mine/4nco) | Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP gp120, BG505 SOSIP gp41, ... | Authors: | Julien, J.-P, Stanfield, R.L, Lyumkis, D, Ward, A.B, Wilson, I.A. | Deposit date: | 2013-10-24 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.7 Å) | Cite: | Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science, 342, 2013
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6NC2
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![BU of 6nc2 by Molmil](/molmil-images/mine/6nc2) | AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC011 v4.2 SOSIP gp120, ... | Authors: | Cottrell, C.A, Ozorowski, G, Yuan, M, Copps, J, Wilson, I.A, Ward, A.B. | Deposit date: | 2018-12-10 | Release date: | 2019-06-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies. Cell Host Microbe, 25, 2019
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6NC3
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![BU of 6nc3 by Molmil](/molmil-images/mine/6nc3) | AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env AMC011 v4.2 SOSIP gp120, ... | Authors: | Cottrell, C.A, Ozorowski, G, Torres, J.L, Ward, A.B. | Deposit date: | 2018-12-10 | Release date: | 2019-06-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies. Cell Host Microbe, 25, 2019
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6NFC
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![BU of 6nfc by Molmil](/molmil-images/mine/6nfc) | BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG18-like precursor HMP42 fragment antigen binding heavy chain, ... | Authors: | Ozorowski, G, Torres, J.L, Ward, A.B. | Deposit date: | 2018-12-19 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science, 366, 2019
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6VKN
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![BU of 6vkn by Molmil](/molmil-images/mine/6vkn) | BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Cottrell, C.A, Ward, A.B. | Deposit date: | 2020-01-21 | Release date: | 2020-08-12 | Last modified: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020
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6VV5
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![BU of 6vv5 by Molmil](/molmil-images/mine/6vv5) | |
5AIV
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![BU of 5aiv by Molmil](/molmil-images/mine/5aiv) | Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor. | Descriptor: | 3-(1H-indol-4-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-5-carboxamide, GLUTATHIONE, HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, ... | Authors: | Edfeldt, F, Evenas, J, Lepisto, M, Ward, A, Petersen, J, Wissler, L, Rohman, M, Sivars, U, Svensson, K, Perry, M, Feierberg, I, Zhou, X, Hansson, T, Narjes, F. | Deposit date: | 2015-02-17 | Release date: | 2015-06-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds). Bioorg.Med.Chem.Lett., 25, 2015
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6MGV
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![BU of 6mgv by Molmil](/molmil-images/mine/6mgv) | |
6MGW
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![BU of 6mgw by Molmil](/molmil-images/mine/6mgw) | |
6VO0
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![BU of 6vo0 by Molmil](/molmil-images/mine/6vo0) | BG505 SOSIP.v5.2 in complex with rabbit Fab 43A2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 43A2 heavy chain, ... | Authors: | Nogal, B, Cottrell, C.A, Ward, A.B. | Deposit date: | 2020-01-29 | Release date: | 2020-07-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite. Sci Adv, 6, 2020
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6NIJ
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![BU of 6nij by Molmil](/molmil-images/mine/6nij) | PGT145 Fab in complex with full length AMC011 HIV-1 Env | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC011 Glycoprotein 120, ... | Authors: | Cottrell, C.A, Torrents de la Pena, A, Rantalainen, K, Torres, J.L, Ward, A.B. | Deposit date: | 2018-12-29 | Release date: | 2019-07-31 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics. Plos Pathog., 15, 2019
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6NF6
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![BU of 6nf6 by Molmil](/molmil-images/mine/6nf6) | Structure of chicken Otop3 in nanodiscs | Descriptor: | CHOLESTEROL HEMISUCCINATE, Otopetrin3 | Authors: | Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B. | Deposit date: | 2018-12-18 | Release date: | 2019-06-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structures of the otopetrin proton channels Otop1 and Otop3. Nat.Struct.Mol.Biol., 26, 2019
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6NF4
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![BU of 6nf4 by Molmil](/molmil-images/mine/6nf4) | Structure of zebrafish Otop1 in nanodiscs | Descriptor: | CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, Otopetrin1 | Authors: | Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B. | Deposit date: | 2018-12-18 | Release date: | 2019-06-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structures of the otopetrin proton channels Otop1 and Otop3. Nat.Struct.Mol.Biol., 26, 2019
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6X9S
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![BU of 6x9s by Molmil](/molmil-images/mine/6x9s) | |
6X9R
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6X9U
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![BU of 6x9u by Molmil](/molmil-images/mine/6x9u) | HIV-1 Envelope Glycoprotein BG505 SOSIP.664, expressed in HEK293S cells and partially deglycosylated by endoglycosidase H, in complex with RM20A3 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp120, ... | Authors: | Berndsen, Z.T, Ward, A.B. | Deposit date: | 2020-06-03 | Release date: | 2020-11-04 | Last modified: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Visualization of the HIV-1 Env glycan shield across scales. Proc.Natl.Acad.Sci.USA, 117, 2020
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2PZY
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![BU of 2pzy by Molmil](/molmil-images/mine/2pzy) | Structure of MK2 Complexed with Compound 76 | Descriptor: | (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, MAP kinase-activated protein kinase 2, STAUROSPORINE | Authors: | White, A, Wu, J.P, Wang, J, Abeywardane, A, Andersen, D, Emmanuel, M, Gautschi, E, Goldberg, D.R, Kashem, M.A, Lukas, S, Mao, W, Martin, L, Morwick, T, Moss, N, Pargellis, C, Patel, U.R, Patnaude, L, Peet, G.W, Skow, D, Snow, R.J, Ward, Y, Werneburg, B. | Deposit date: | 2007-05-18 | Release date: | 2007-07-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The discovery of carboline analogs as potent MAPKAP-K2 inhibitors Bioorg.Med.Chem.Lett., 17, 2007
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4URJ
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![BU of 4urj by Molmil](/molmil-images/mine/4urj) | Crystal structure of human BJ-TSA-9 | Descriptor: | 1,2-ETHANEDIOL, PROTEIN FAM83A | Authors: | Pinkas, D.M, Sanvitale, C, Wang, D, Krojer, T, Kopec, J, Chaikuad, A, Dixon Clarke, S, Berridge, G, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Bullock, A. | Deposit date: | 2014-06-30 | Release date: | 2014-10-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Crystal Structure of Human Bj-Tsa-9 To be Published
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5AIX
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![BU of 5aix by Molmil](/molmil-images/mine/5aix) | Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor. | Descriptor: | 6-(3-methoxyphenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide, GLUTATHIONE, HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, ... | Authors: | Edfeldt, F, Evenas, J, Lepisto, M, Ward, A, Petersen, J, Wissler, L, Rohman, M, Sivars, U, Svensson, K, Perry, M, Feierberg, I, Zhou, X, Hansson, T, Narjes, F. | Deposit date: | 2015-02-18 | Release date: | 2015-06-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds). Bioorg.Med.Chem.Lett., 25, 2015
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6OHY
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![BU of 6ohy by Molmil](/molmil-images/mine/6ohy) | Chimpanzee SIV Env trimeric ectodomain. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Pallesen, J, Andrabi, R, de Val, N, Burton, D.R, Ward, A.B. | Deposit date: | 2019-04-08 | Release date: | 2019-06-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template. Cell Rep, 27, 2019
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6OZC
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![BU of 6ozc by Molmil](/molmil-images/mine/6ozc) | BG505 SOSIP.664 with 2G12 Fab2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2G12 Fab Heavy chain, ... | Authors: | Cottrell, C.A, Ward, A.B. | Deposit date: | 2019-05-15 | Release date: | 2020-05-20 | Last modified: | 2020-08-19 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions. Structure, 28, 2020
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6P6F
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![BU of 6p6f by Molmil](/molmil-images/mine/6p6f) | BG505 SOSIP-I53-50NP | Descriptor: | I53-50A.1NT1, I53-50B.4PT1 | Authors: | Berndsen, Z.T, Ward, A.B. | Deposit date: | 2019-06-03 | Release date: | 2019-06-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Nat Commun, 10, 2019
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4NHH
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![BU of 4nhh by Molmil](/molmil-images/mine/4nhh) | Structure of 2G12 IgG Dimer | Descriptor: | 2G12 IgG dimer heavy chain, 2G12 IgG dimer light chain, Hepatitis B virus receptor binding protein | Authors: | Wu, Y, West Jr, A.P, Kim, H.J, Thornton, M.E, Ward, A.B, Bjorkman, P.J. | Deposit date: | 2013-11-05 | Release date: | 2014-02-26 | Method: | X-RAY DIFFRACTION (6.5 Å) | Cite: | Structural basis for enhanced HIV-1 neutralization by a dimeric immunoglobulin G form of the glycan-recognizing antibody 2G12. Cell Rep, 5, 2013
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6NUS
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![BU of 6nus by Molmil](/molmil-images/mine/6nus) | |