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5AIV

Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor.

Summary for 5AIV
Entry DOI10.2210/pdb5aiv/pdb
Related5AIS
DescriptorHEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, 3-(1H-indol-4-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-5-carboxamide, GLUTATHIONE, ... (5 entities in total)
Functional Keywordstransferase, prostaglandin d2 synthase, pgds inhibitors, indole, focused screening, hit validation
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm : O60760
Total number of polymer chains4
Total formula weight95990.01
Authors
Edfeldt, F.,Evenas, J.,Lepisto, M.,Ward, A.,Petersen, J.,Wissler, L.,Rohman, M.,Sivars, U.,Svensson, K.,Perry, M.,Feierberg, I.,Zhou, X.,Hansson, T.,Narjes, F. (deposition date: 2015-02-17, release date: 2015-06-03, Last modification date: 2015-06-10)
Primary citationEdfeldt, F.,Even, J.,Lepisto, M.,Ward, A.,Petersen, J.,Wissler, L.,Rohman, M.,Sivars, U.,Svensson, K.,Perry, M.,Feierberg, I.,Zhou, X.H.,Hansson, T.,Narjes, F.
Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25:2496-, 2015
Cited by
PubMed: 25978964
DOI: 10.1016/J.BMCL.2015.04.065
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

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