5AIX

Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor.

Summary for 5AIX

Entry DOI	10.2210/pdb5aix/pdb
Related	5AIS 5AIV
Descriptor	HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, MAGNESIUM ION, GLUTATHIONE, ... (5 entities in total)
Functional Keywords	transferase, prostaglandin d2 synthase, pgds inhibitors, indole, focused screening, hit validation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : O60760
Total number of polymer chains	4
Total formula weight	94960.92
Authors	Edfeldt, F.,Evenas, J.,Lepisto, M.,Ward, A.,Petersen, J.,Wissler, L.,Rohman, M.,Sivars, U.,Svensson, K.,Perry, M.,Feierberg, I.,Zhou, X.,Hansson, T.,Narjes, F. (deposition date: 2015-02-18, release date: 2015-06-03, Last modification date: 2015-06-10)
Primary citation	Edfeldt, F.,Even, J.,Lepisto, M.,Ward, A.,Petersen, J.,Wissler, L.,Rohman, M.,Sivars, U.,Svensson, K.,Perry, M.,Feierberg, I.,Zhou, X.H.,Hansson, T.,Narjes, F. Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds). Bioorg.Med.Chem.Lett., 25:2496-, 2015 Cited by PubMed: 25978964 DOI: 10.1016/J.BMCL.2015.04.065 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation