5AIX
Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | polymer | 199 | 23377.7 | 4 | UniProt (O60760) Pfam (PF02798) Pfam (PF14497) | HOMO SAPIENS (HUMAN) | H-PGDS, GST CLASS-SIGMA, GLUTATHIONE S-TRANSFERASE, GLUTATH IONE-DEPENDENT PGD SYNTHASE, GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, PROSTAGLANDIN-H2 D-ISOMERASE |
| 2 | E, J (A, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | F, H (B, C) | GLUTATHIONE | non-polymer | 307.3 | 2 | Chemie (GSH) | |||
| 4 | G, I (B, C) | 6-(3-methoxyphenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide | non-polymer | 393.4 | 2 | Chemie (KRX) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 199 (UniProt: O60760)
| PDB | External Database | Details |
|---|---|---|
| His 1 | - | expression tag |
| Glu 73 | Lys 73 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93510.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1450.1 | |
| All* | Total formula weight | 94960.9 |
