8JXU
| Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 2, ... | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-07-01 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JXQ
| Cryo-EM structure of bilirubin ditaurate (BDT) bound human ABC transporter ABCC2 | 分子名称: | 2-[3-[5-[(E)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-3-[3-oxidanylidene-3-(2-sulfoethylamino)propyl]-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoylamino]ethanesulfonic acid, ATP-binding cassette sub-family C member 2, CHOLESTEROL | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-07-01 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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4LTS
| Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors | 分子名称: | 1,2-ETHANEDIOL, 2-cyano-1-pyridin-4-yl-3-(4-{[3-(trifluoromethoxy)phenyl]sulfonyl}benzyl)guanidine, Nicotinamide phosphoribosyltransferase, ... | 著者 | Zheng, X, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynoids, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Oh, A, Wang, W, Zak, M, Wang, L, Yuen, P, Bair, K.W. | 登録日 | 2013-07-23 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.692 Å) | 主引用文献 | Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
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4LWW
| Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors | 分子名称: | 1,2-ETHANEDIOL, N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Zheng, X, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynoids, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Oh, A, Wang, W, Zak, M, Wang, L, Yuen, P, Bair, K.W. | 登録日 | 2013-07-28 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.641 Å) | 主引用文献 | Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
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7E6T
| Structural insights into the activation of human calcium-sensing receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CYCLOMETHYLTRYPTOPHAN, ... | 著者 | Geng, Y, Chen, X.C, Wang, L, Cui, Q.Q, Ding, Z.Y, Han, L, Kou, Y.J, Zhang, W.Q, Wang, H.N, Jia, X.M, Dai, M, Shi, Z.Z, Li, Y.Y, Li, X.Y. | 登録日 | 2021-02-24 | 公開日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into the activation of human calcium-sensing receptor. Elife, 10, 2021
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7E6U
| the complex of inactive CaSR and NB2D11 | 分子名称: | Extracellular calcium-sensing receptor, NB-2D11 | 著者 | Geng, Y, Chen, X.C, Wang, L, Cui, Q.Q, Ding, Z.Y, Han, L, Kou, Y.J, Zhang, W.Q, Wang, H.N, Jia, X.M, Dai, M, Shi, Z.Z, Li, Y.Y, Li, X.Y. | 登録日 | 2021-02-24 | 公開日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Structural insights into the activation of human calcium-sensing receptor. Elife, 10, 2021
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5UDZ
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7ENQ
| Crystal structure of human NAMPT in complex with compound NAT | 分子名称: | 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | 著者 | Wang, G, Wu, C, Liu, M, Yao, H, Li, C, Wang, L, Tang, Y. | 登録日 | 2021-04-19 | 公開日 | 2022-05-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.204966 Å) | 主引用文献 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res., 32, 2022
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5W1C
| Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cytidine | 分子名称: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3'), ... | 著者 | Qiao, Q, Wang, L, Wu, H. | 登録日 | 2017-06-02 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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3P12
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5W0Z
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5W0R
| Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cacodylic acid | 分子名称: | CACODYLATE ION, CALCIUM ION, MBP fused activation-induced cytidine deaminase, ... | 著者 | Qiao, Q, Wang, L, Wu, H. | 登録日 | 2017-05-31 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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5W0U
| Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with dCMP | 分子名称: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3'), ... | 著者 | Qiao, Q, Wang, L, Wu, H. | 登録日 | 2017-05-31 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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3P13
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7WT9
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7WT8
| SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 9A8, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2022-02-04 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD. Cell Discov, 8, 2022
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7WT7
| SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 9A8, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2022-02-04 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD. Cell Discov, 8, 2022
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4JI3
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | 分子名称: | 16S rRNA, MAGNESIUM ION, RIBOSOMAL PROTEIN S10, ... | 著者 | Demirci, H, Wang, L, Murphy, F.V, Murphy, E.L, Carr, J, Blanchard, S, Jogl, G, Dahlberg, A.E, Gregory, S.T. | 登録日 | 2013-03-05 | 公開日 | 2013-11-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | The central role of protein S12 in organizing the structure of the decoding site of the ribosome. Rna, 19, 2013
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6JBJ
| Cryo-EM structure of human lysosomal cobalamin exporter ABCD4 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family D member 4 | 著者 | Xu, D, Feng, Z, Hou, W.T, Jiang, Y.L, Wang, L, Sun, L.F, Zhou, C.Z, Chen, Y. | 登録日 | 2019-01-25 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of human lysosomal cobalamin exporter ABCD4. Cell Res., 29, 2019
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4JI1
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | 分子名称: | 16S rRNA, MAGNESIUM ION, RIBOSOMAL PROTEIN S10, ... | 著者 | Demirci, H, Wang, L, Murphy IV, F, Murphy, E, Carr, J, Blanchard, S, Jogl, G, Dahlberg, A.E, Gregory, S.T. | 登録日 | 2013-03-05 | 公開日 | 2013-11-06 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.144 Å) | 主引用文献 | The central role of protein S12 in organizing the structure of the decoding site of the ribosome. Rna, 19, 2013
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4JI5
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | 分子名称: | 16S rRNA, MAGNESIUM ION, RIBOSOMAL PROTEIN S10, ... | 著者 | Demirci, H, Wang, L, Murphy IV, F, Murphy, E, Carr, J, Blanchard, S, Jogl, G, Dahlberg, A.E, Gregory, S.T. | 登録日 | 2013-03-05 | 公開日 | 2013-11-06 | 最終更新日 | 2013-12-04 | 実験手法 | X-RAY DIFFRACTION (3.85 Å) | 主引用文献 | The central role of protein S12 in organizing the structure of the decoding site of the ribosome. Rna, 19, 2013
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4JI4
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | 分子名称: | 16S rRNA, MAGNESIUM ION, RIBOSOMAL PROTEIN S10, ... | 著者 | Demirci, H, Wang, L, Murphy IV, F, Murphy, E, Carr, J, Blanchard, S, Jogl, G, Dahlberg, A.E, Gregory, S.T. | 登録日 | 2013-03-05 | 公開日 | 2013-11-06 | 最終更新日 | 2013-12-04 | 実験手法 | X-RAY DIFFRACTION (3.692 Å) | 主引用文献 | The central role of protein S12 in organizing the structure of the decoding site of the ribosome. Rna, 19, 2013
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4JI8
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | 分子名称: | 16S rRNA, MAGNESIUM ION, RIBOSOMAL PROTEIN S10, ... | 著者 | Demirci, H, Wang, L, Murphy IV, F, Murphy, E, Carr, J, Blanchard, S, Jogl, G, Dahlberg, A.E, Gregory, S.T. | 登録日 | 2013-03-05 | 公開日 | 2013-11-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.742 Å) | 主引用文献 | The central role of protein S12 in organizing the structure of the decoding site of the ribosome. Rna, 19, 2013
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8HP6
| Crystal structure of (S)-2-haloacid dehalogenase D12A mutant | 分子名称: | (S)-2-haloacid dehalogenase, SODIUM ION | 著者 | Yang, Q, Wang, L, Xu, X, Xing, X, Zhou, J. | 登録日 | 2022-12-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening Catalysis Science And Technology, 2023
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8HP5
| Crystal structure of (S)-2-haloacid dehalogenase | 分子名称: | (S)-2-haloacid dehalogenase, 1,2-ETHANEDIOL | 著者 | Yang, Q, Wang, L, Xu, X, Xing, X, Zhou, J. | 登録日 | 2022-12-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening Catalysis Science And Technology, 2023
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