8JXU

Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition

Summary for 8JXU

Entry DOI	10.2210/pdb8jxu/pdb
EMDB information	36713
Descriptor	ATP-binding cassette sub-family C member 2, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	atp-dependent transporter, conjugated organic anions transporter, atp hydrolyzes, transport protein, bilirubin, abc transporter
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	177923.66
Authors	Mao, Y.X.,Chen, Z.P.,Wang, L.,Hou, W.T.,Chen, Y.X.,Zhou, C.Z. (deposition date: 2023-07-01, release date: 2024-01-03, Last modification date: 2024-02-28)
Primary citation	Mao, Y.X.,Chen, Z.P.,Wang, L.,Wang, J.,Zhou, C.Z.,Hou, W.T.,Chen, Y. Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15:1061-1061, 2024 Cited by PubMed: 38316776 DOI: 10.1038/s41467-024-45337-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.55 Å)

Structure validation