8JXU

Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ATP-binding cassette sub-family C member 2	polymer	1565	176965.0	1	UniProt (Q92887) Pfam (PF24357) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (human)	Canalicular multidrug resistance protein,Canalicular multispecific organic anion transporter 1,Multidrug resistance-associated protein 2
2	B (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
3	C (A)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
4	D (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 1 - 1545 (UniProt: Q92887)

PDB	External Database	Details
Leu 1546	-	expression tag
Glu 1547	-	expression tag
Asp 1548	-	expression tag
Tyr 1549	-	expression tag
Lys 1550	-	expression tag
Asp 1551	-	expression tag
Asp 1552	-	expression tag
Asp 1553	-	expression tag
Asp 1554	-	expression tag
Lys 1555	-	expression tag
Val 1556	-	expression tag
Glu 1557	-	expression tag
His 1558	-	expression tag
His 1559	-	expression tag
His 1560	-	expression tag
His 1561	-	expression tag
His 1562	-	expression tag
His 1563	-	expression tag
His 1564	-	expression tag
His 1565	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	176965.0
Non-Polymers*	Number of molecules	3
	Total formula weight	958.7
All*	Total formula weight	177923.7

*Water molecules are not included.