Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4LWW

Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Summary for 4LWW
Entry DOI10.2210/pdb4lww/pdb
Related4LTS
DescriptorNicotinamide phosphoribosyltransferase, N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordstransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity): P43490
Total number of polymer chains2
Total formula weight116226.81
Authors
Primary citationZheng, X.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.C.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Wang, Y.,Yuen, P.W.,Bair, K.W.
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg.Med.Chem.Lett., 24:337-343, 2014
Cited by
PubMed: 24279990
DOI: 10.1016/j.bmcl.2013.11.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.641 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon