4LTS
Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Summary for 4LTS
Entry DOI | 10.2210/pdb4lts/pdb |
Related | 4LWW |
Descriptor | Nicotinamide phosphoribosyltransferase, 2-cyano-1-pyridin-4-yl-3-(4-{[3-(trifluoromethoxy)phenyl]sulfonyl}benzyl)guanidine, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P43490 |
Total number of polymer chains | 2 |
Total formula weight | 115584.19 |
Authors | Zheng, X.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.,Kley, N.,Lin, J.,Reynoids, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Wang, L.,Yuen, P.,Bair, K.W. (deposition date: 2013-07-23, release date: 2013-12-25, Last modification date: 2023-09-20) |
Primary citation | Zheng, X.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.C.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Wang, Y.,Yuen, P.W.,Bair, K.W. Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg.Med.Chem.Lett., 24:337-343, 2014 Cited by PubMed: 24279990DOI: 10.1016/j.bmcl.2013.11.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.692 Å) |
Structure validation
Download full validation report