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PDB: 1452 件
4ORB
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BU of 4orb by Molmil
Crystal structure of mouse calcineurin
分子名称: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ...
著者Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X.
登録日2014-02-11
公開日2015-05-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.108 Å)
主引用文献Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
4ORC
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BU of 4orc by Molmil
Crystal structure of mammalian calcineurin
分子名称: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ...
著者Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X.
登録日2014-02-11
公開日2015-05-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
6WGJ
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BU of 6wgj by Molmil
Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide
分子名称: Dupilumab Fab heavy chain, Dupilumab Fab light chain
著者Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J.
登録日2020-04-05
公開日2020-09-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
6NBN
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BU of 6nbn by Molmil
Structure of Aedes aegypti OBP22 in the complex with arachidonic acid
分子名称: AAEL005772-PA, ARACHIDONIC ACID
著者Jones, D.N, Wang, J.
登録日2018-12-07
公開日2018-12-19
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.
Sci Rep, 10, 2020
7LYI
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BU of 7lyi by Molmil
Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-3
分子名称: 3C-like proteinase, GLYCEROL, SODIUM ION, ...
著者Sacco, M, Wang, J, Chen, Y.
登録日2021-03-07
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
Acs Pharmacol Transl Sci, 4, 2021
7LYH
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BU of 7lyh by Molmil
Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-1
分子名称: 3C-like proteinase, GLYCEROL, benzyl (1S,3aR,6aS)-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
著者Sacco, M, Wang, J, Chen, Y.
登録日2021-03-07
公開日2021-03-17
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
Acs Pharmacol Transl Sci, 4, 2021
6OGH
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BU of 6ogh by Molmil
Structure of Aedes aegypti OBP22 in the complex with linoleic acid
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AAEL005772-PA, CADMIUM ION, ...
著者Jones, D.N, Wang, J.
登録日2019-04-02
公開日2019-04-24
最終更新日2020-05-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.
Sci Rep, 10, 2020
6OG0
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BU of 6og0 by Molmil
Structure of Aedes aegypti OBP22
分子名称: AAEL005772-PA, CADMIUM ION, CHLORIDE ION
著者Jones, D.N, Wang, J.
登録日2019-04-01
公開日2019-04-17
最終更新日2020-05-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.
Sci Rep, 10, 2020
6EDJ
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BU of 6edj by Molmil
Cryo-EM structure of Woodchuck hepatitis virus capsid
分子名称: External core antigen
著者Zhao, Z, Wang, J.C, Zlotnick, A.
登録日2018-08-09
公開日2019-05-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.52 Å)
主引用文献Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly.
J.Virol., 93, 2019
4YOM
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BU of 4yom by Molmil
Structure of SAD kinase
分子名称: 1,2-ETHANEDIOL, Serine/threonine-protein kinase BRSK2
著者Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W.
登録日2015-03-12
公開日2015-12-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
Nat Commun, 6, 2015
3WUZ
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BU of 3wuz by Molmil
Crystal structure of the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha
分子名称: CITRIC ACID, ISOPROPYL ALCOHOL, Paired immunoglobulin-like type 2 receptor alpha
著者Kuroki, K, Wang, J, Ose, T, Yamaguchi, M, Tabata, S, Maita, N, Nakamura, S, Kajikawa, M, Kogure, A, Satoh, T, Arase, H, Maenaka, K.
登録日2014-05-10
公開日2014-06-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR alpha
Proc.Natl.Acad.Sci.USA, 111, 2014
6LTU
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BU of 6ltu by Molmil
Crystal structure of Cas12i2 ternary complex with double Mg2+ bound in catalytic pocket
分子名称: 1,2-ETHANEDIOL, Cas12i2, DNA (35-MER), ...
著者Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y.
登録日2020-01-23
公開日2020-10-28
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
Nat Commun, 11, 2020
3J9L
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BU of 3j9l by Molmil
Structure of Dark apoptosome from Drosophila melanogaster
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apaf-1 related killer DARK
著者Pang, Y, Bai, X, Yan, C, Hao, Q, Chen, Z, Wang, J, Scheres, S.H.W, Shi, Y.
登録日2015-02-04
公開日2015-02-25
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29, 2015
6XF3
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BU of 6xf3 by Molmil
Crystal structure of STING in complex with E7766
分子名称: (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name), Stimulator of interferon genes protein
著者Chen, Y, Wang, J.Y, Kim, D.-S.
登録日2020-06-15
公開日2021-02-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.
Chemmedchem, 16, 2021
6LTR
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BU of 6ltr by Molmil
Crystal structure of Cas12i2 ternary complex with single Mg2+ bound in catalytic pocket
分子名称: 1,2-ETHANEDIOL, Cas12i2, DNA (35-MER), ...
著者Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y.
登録日2020-01-23
公開日2020-10-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
Nat Commun, 11, 2020
4LMQ
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BU of 4lmq by Molmil
Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
分子名称: Stromal cell-derived factor 1, hu30D8 Fab heavy chain, hu30D8 Fab light chain
著者Zhong, Z, Wang, J, Li, B, Xiang, H, Ultsch, M, Coons, M, Wong, T, Chiang, N.Y, Clark, S, Clark, R, Quintana, L, Gribling, P, Suto, E, Barck, K, Corpuz, R, Yao, J, Takkar, R, Lee, W.P, Damico-Beyer, L.A, Carano, R.D, Adams, C, Kelley, R.F, Wang, W, Ferrara, N.
登録日2013-07-10
公開日2013-08-14
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.773 Å)
主引用文献Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12.
Clin.Cancer Res., 19, 2013
4OR9
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BU of 4or9 by Molmil
Crystal structure of human calcineurin
分子名称: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ...
著者Li, S.J, Wang, J, Wu, J.W, Wang, Z.X.
登録日2014-02-11
公開日2015-05-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
2ERF
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BU of 2erf by Molmil
Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution
分子名称: Thrombospondin-1
著者Tan, K, Wang, J, Lawler, J.
登録日2005-10-24
公開日2006-01-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin.
Structure, 14, 2006
3J9K
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BU of 3j9k by Molmil
Structure of Dark apoptosome in complex with Dronc CARD domain
分子名称: ADENOSINE-5'-DIPHOSPHATE, Apaf-1 related killer DARK, Caspase Nc
著者Pang, Y, Bai, X, Yan, C, Hao, Q, Chen, Z, Wang, J, Scheres, S.H.W, Shi, Y.
登録日2015-02-04
公開日2015-02-25
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29, 2015
1YYB
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BU of 1yyb by Molmil
Solution structure of 1-26 fragment of human programmed cell death 5 protein
分子名称: Programmed cell death protein 5
著者Liu, D.S, Feng, Y.G, Yao, H.W, Wang, J.F.
登録日2005-02-24
公開日2005-09-13
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable alpha-helix having unique electrostatic potential character.
Biochem.J., 392, 2005
6WGK
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BU of 6wgk by Molmil
Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide
分子名称: Dupilumab Fab heavy chain, Dupilumab Fab light chain
著者Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J.
登録日2020-04-05
公開日2020-09-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
5ZAM
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BU of 5zam by Molmil
Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate
分子名称: Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer)
著者Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W.
登録日2018-02-07
公開日2018-05-09
最終更新日2020-08-05
実験手法ELECTRON MICROSCOPY (5.7 Å)
主引用文献Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.
Cell, 173, 2018
4N47
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BU of 4n47 by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA and 12-mer target DNA
分子名称: 5'-D(*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ...
著者Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
登録日2013-10-08
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.823 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
1EFG
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BU of 1efg by Molmil
THE CRYSTAL STRUCTURE OF ELONGATION FACTOR G COMPLEXED WITH GDP, AT 2.7 ANGSTROMS RESOLUTION
分子名称: ELONGATION FACTOR G, GUANOSINE-5'-DIPHOSPHATE
著者Czworkowski, J, Wang, J, Steitz, T.A, Moore, P.B.
登録日1994-10-17
公開日1995-02-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution.
EMBO J., 13, 1994
4YNZ
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BU of 4ynz by Molmil
Structure of the N-terminal domain of SAD
分子名称: Serine/threonine-protein kinase BRSK2
著者Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W.
登録日2015-03-11
公開日2015-12-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
Nat Commun, 6, 2015

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