6WLW
 
 | | The Vo region of human V-ATPase in state 1 (focused refinement) | | Descriptor: | (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wang, L, Wu, H, Fu, T.-M. | | Deposit date: | 2020-04-20 | | Release date: | 2020-11-11 | | Last modified: | 2020-11-25 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
Mol.Cell, 80, 2020
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6TR3
 | | Ruminococcus gnavus GH29 fucosidase E1_10125 in complex with fucose | | Descriptor: | CALCIUM ION, F5/8 type C domain-containing protein, MAGNESIUM ION, ... | | Authors: | Owen, C.D, Wu, H, Crost, E, Colvile, A, Juge, N, Walsh, M.A. | | Deposit date: | 2019-12-17 | | Release date: | 2020-10-28 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Fucosidases from the human gut symbiont Ruminococcus gnavus.
Cell.Mol.Life Sci., 78, 2021
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6TR4
 | | Ruminococcus gnavus GH29 fucosidase E1_10125 D221A mutant in complex with fucose | | Descriptor: | CALCIUM ION, CHLORIDE ION, F5/8 type C domain-containing protein, ... | | Authors: | Owen, C.D, Wu, H, Crost, E, Colvile, A, Juge, N, Walsh, M.A. | | Deposit date: | 2019-12-17 | | Release date: | 2020-10-28 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Fucosidases from the human gut symbiont Ruminococcus gnavus.
Cell.Mol.Life Sci., 78, 2021
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2VXK
 | | Structural comparison between Aspergillus fumigatus and human GNA1 | | Descriptor: | 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, COENZYME A, GLUCOSAMINE 6-PHOSPHATE ACETYLTRANSFERASE, ... | | Authors: | Hurtado-Guerrero, R, Raimi, O.G, Min, J, Zeng, H, Vallius, L, Shepherd, S, Ibrahim, A.F.M, Wu, H, Plotnikov, A.N, van Aalten, D.M.F. | | Deposit date: | 2008-07-05 | | Release date: | 2008-07-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural and Kinetic Differences between Human and Aspergillus Fumigatus D-Glucosamine-6- Phosphate N-Acetyltransferase.
Biochem.J., 415, 2008
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8CZO
 | | Cryo-EM structure of BCL10 CARD - MALT1 DD filament | | Descriptor: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | | Authors: | David, L, Wu, H. | | Deposit date: | 2022-05-25 | | Release date: | 2022-06-22 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
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8CZD
 | | Cryo-EM structure of BCL10 R58Q filament | | Descriptor: | B-cell lymphoma/leukemia 10 | | Authors: | David, L, Wu, H. | | Deposit date: | 2022-05-24 | | Release date: | 2022-06-22 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
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8E4Y
 | | Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with 2-oxohexadecyl-CoA | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate, Glycerol-3-phosphate acyltransferase 1, mitochondrial, ... | | Authors: | Johnson, Z.L, Wasilko, D.J, Ammirati, M, Chang, J.S, Han, S, Wu, H. | | Deposit date: | 2022-08-19 | | Release date: | 2022-12-21 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of the acyl-transfer mechanism of human GPAT1.
Nat.Struct.Mol.Biol., 30, 2023
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8E50
 | | Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with CoA and palmitoyl-LPA | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate, COENZYME A, Glycerol-3-phosphate acyltransferase 1, ... | | Authors: | Wasilko, D.J, Johnson, Z.L, Ammirati, M, Chang, J.S, Han, S, Wu, H. | | Deposit date: | 2022-08-19 | | Release date: | 2022-12-21 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Structural basis of the acyl-transfer mechanism of human GPAT1.
Nat.Struct.Mol.Biol., 30, 2023
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3JBL
 | | Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization | | Descriptor: | NLR family CARD domain-containing protein 4 | | Authors: | Zhang, L, Chen, S, Ruan, J, Wu, J, Tong, A.B, Yin, Q, Li, Y, David, L, Lu, A, Wang, W.L, Marks, C, Ouyang, Q, Zhang, X, Mao, Y, Wu, H. | | Deposit date: | 2015-09-05 | | Release date: | 2015-10-21 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350, 2015
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6WLZ
 | | The V1 region of human V-ATPase in state 1 (focused refinement) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SidK, V-type proton ATPase catalytic subunit A, ... | | Authors: | Wang, L, Wu, H, Fu, T.M. | | Deposit date: | 2020-04-20 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
Mol.Cell, 80, 2020
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6SCX
 | | Crystal structure of the catalytic domain of human NUDT12 in complex with 7-methyl-guanosine-5'-triphosphate | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, CADMIUM ION, Peroxisomal NADH pyrophosphatase NUDT12 | | Authors: | McCarthy, A.A, Chen, K.M, Wu, H, Li, L, Homolka, D, Gos, P, Fleury-Olela, F, Pillai, R.S. | | Deposit date: | 2019-07-25 | | Release date: | 2020-01-08 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.92 Å) | | Cite: | Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
Cell Rep, 29, 2019
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8E4C
 | | IgM BCR fab truncated form | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain,Yellow fluorescent protein, B-cell antigen receptor complex-associated protein beta chain, ... | | Authors: | Dong, Y, Pi, X, Wu, H, Reth, M. | | Deposit date: | 2022-08-18 | | Release date: | 2022-11-16 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural principles of B cell antigen receptor assembly.
Nature, 612, 2022
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2F5H
 | | Solution structure of the alpha-domain of human Metallothionein-3 | | Descriptor: | CADMIUM ION, Metallothionein-3 | | Authors: | Wang, H, Zhang, Q, Cai, B, Li, H.Y, Sze, K.H, Huang, Z.X, Wu, H.M, Sun, H.Z. | | Deposit date: | 2005-11-25 | | Release date: | 2006-05-30 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure and dynamics of human metallothionein-3 (MT-3)
Febs Lett., 580, 2006
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1FLL
 | | MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3 | | Descriptor: | B-CELL SURFACE ANTIGEN CD40, TNF RECEPTOR ASSOCIATED FACTOR 3 | | Authors: | Ni, C.-Z, Welsh, K, Leo, E, Chiou, C.-K, Wu, H, Reed, J.C, Ely, K.R. | | Deposit date: | 2000-08-14 | | Release date: | 2000-10-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Molecular basis for CD40 signaling mediated by TRAF3.
Proc.Natl.Acad.Sci.USA, 97, 2000
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1FRY
 | | THE SOLUTION STRUCTURE OF SHEEP MYELOID ANTIMICROBIAL PEPTIDE, RESIDUES 1-29 (SMAP29) | | Descriptor: | MYELOID ANTIMICROBIAL PEPTIDE | | Authors: | Tack, B.F, Sawai, M.V, Kearney, W.R, Robertson, A.D, Sherman, M.A, Wang, W, Hong, T, Boo, L.M, Wu, H, Waring, A.J, Lehrer, R.I. | | Deposit date: | 2000-09-07 | | Release date: | 2002-03-08 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | SMAP-29 has two LPS-binding sites and a central hinge.
Eur.J.Biochem., 269, 2002
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8SPB
 | | Caspase-4/Pro-IL-18 complex | | Descriptor: | Caspase-4 subunit p10, Caspase-4 subunit p20, Interleukin-18 | | Authors: | Pascal, D, Dong, Y, Wu, H, Jon, K. | | Deposit date: | 2023-05-02 | | Release date: | 2023-11-22 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into cytokine cleavage by inflammatory caspase-4.
Nature, 624, 2023
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7LFH
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8SV1
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2EUY
 | | Solution structure of the internal loop of human U65 H/ACA snoRNA 3' hairpin | | Descriptor: | U65 box H/ACA snoRNA | | Authors: | Feigon, J, Khanna, M, Wu, H, Johansson, C, Caizergues-Ferrer, M. | | Deposit date: | 2005-10-30 | | Release date: | 2006-01-03 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA.
Rna, 12, 2006
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3JBW
 | | Cryo-electron microscopy structure of RAG Paired Complex (with NBD, no symmetry) | | Descriptor: | 12-RSS signal end forward strand, 5'-D(P*GP*AP*TP*CP*TP*GP*GP*CP*CP*TP*GP*TP*CP*TP*TP*A)-3', Nicked 12-RSS intermediate reverse strand, ... | | Authors: | Ru, H, Chambers, M.G, Fu, T.-M, Tong, A.B, Liao, M, Wu, H. | | Deposit date: | 2015-10-21 | | Release date: | 2015-12-09 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.
Cell(Cambridge,Mass.), 163, 2015
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1D0A
 | | STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) IN COMPLEX WITH A HUMAN OX40 PEPTIDE | | Descriptor: | OX40L RECEPTOR PEPTIDE, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | | Deposit date: | 1999-09-09 | | Release date: | 2000-03-08 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2.
Mol.Cell, 4, 1999
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1D0J
 | | STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A M4-1BB PEPTIDE | | Descriptor: | 4-1BB LIGAND RECEPTOR, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | | Deposit date: | 1999-09-10 | | Release date: | 2000-03-08 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2.
Mol.Cell, 4, 1999
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2B9E
 | | Human NSUN5 protein | | Descriptor: | NOL1/NOP2/Sun domain family, member 5 isoform 2, S-ADENOSYLMETHIONINE | | Authors: | Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2005-10-11 | | Release date: | 2005-10-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The Crystal Structure of Human NSUN5 protein in complex with
S-adenosyl-L-methionine
To be Published
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1CZZ
 | | STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 17-RESIDUE CD40 PEPTIDE | | Descriptor: | CD 40 PEPTIDE, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | | Deposit date: | 1999-09-07 | | Release date: | 2000-03-08 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2.
Mol.Cell, 4, 1999
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1D00
 | | STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE | | Descriptor: | B-CELL SURFACE ANTIGEN CD40, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | | Deposit date: | 1999-09-07 | | Release date: | 2000-03-29 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2.
Mol.Cell, 4, 1999
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