4M6L
| Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Dihydrofolate reductase, N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid, ... | 著者 | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | 登録日 | 2013-08-09 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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4M6J
| Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH | 分子名称: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | 登録日 | 2013-08-09 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.201 Å) | 主引用文献 | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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4M5Y
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4M6K
| Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and folate | 分子名称: | Dihydrofolate reductase, FOLIC ACID, GLYCEROL, ... | 著者 | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | 登録日 | 2013-08-09 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.396 Å) | 主引用文献 | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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4MHH
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4QDH
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4MAS
| High Resolution Structure of Wild Type Human Transthyretin in Complex with 3,3',5,5'-tetrachloro-[1,1'-biphenyl]-4,4'diol | 分子名称: | 3,5,3',5'-TETRACHLORO-BIPHENYL-4,4'-DIOL, Transthyretin | 著者 | Connelly, S, Bradbury, N.C, Wilson, I.A. | 登録日 | 2013-08-16 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | 主引用文献 | High Resolution Structure of Wild Type Human Transthyretin in Complex with 3,3',5,5'-tetrachloro-[1,1'-biphenyl]-4,4'diol To be Published
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8FO3
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8FO4
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8FO5
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4L1T
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4R26
| Crystal structure of human Fab PGT124, a broadly neutralizing and potent HIV-1 neutralizing antibody | 分子名称: | GLYCEROL, PGR124-Light Chain, PGT124-Heavy Chain | 著者 | Garces, F, Kong, L, Wilson, I.A. | 登録日 | 2014-08-08 | 公開日 | 2014-10-08 | 最終更新日 | 2017-06-21 | 実験手法 | X-RAY DIFFRACTION (2.4969 Å) | 主引用文献 | Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies. Cell(Cambridge,Mass.), 159, 2014
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4R2G
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4M4Y
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4MHJ
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4MZE
| Crystal structure of hPIV3 hemagglutinin-neuraminidase, H552Q/Q559R mutant | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Xu, R, Wilson, I.A. | 登録日 | 2013-09-30 | 公開日 | 2013-11-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo. MBio, 4, 2013
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4L1S
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4RBP
| Crystal structure of HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomanose | 分子名称: | Fab 2G12 heavy chain, Fab 2G12 light chain, GLYCEROL, ... | 著者 | Stanfield, R.L, Wilson, I.A, De Castro, C, Marzaioli, A.M, Pantophlet, R. | 登録日 | 2014-09-12 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose. Glycobiology, 25, 2015
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4JPK
| Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ... | 著者 | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | 登録日 | 2013-03-19 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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4LG2
| Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA | 分子名称: | Polymerase cofactor, dsRNA | 著者 | Bale, S, Julien, J.-P, Bornholdt, Z.A, Krois, A.S, Wilson, I.A, Saphire, E.O. | 登録日 | 2013-06-27 | 公開日 | 2013-07-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. J.Virol., 87, 2013
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4RQQ
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4QGT
| The Crystal Structure of Human IgG Fc Domain with Enhanced Aromatic Sequon | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Kong, L, Connelly, S.C, Wilson, I.A. | 登録日 | 2014-05-25 | 公開日 | 2015-04-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chem.Biol., 11, 2016
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4N61
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4K3H
| Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green | 分子名称: | 4-{bis[4-(dimethylamino)phenyl]methyl}phenol, GLYCEROL, Immunoglobulin lambda variable domain L5(L89S), ... | 著者 | Stanfield, R.L, Szent-Gyorgyi, C, Wilson, I.A. | 登録日 | 2013-04-10 | 公開日 | 2013-10-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Malachite Green Mediates Homodimerization of Antibody VL Domains to Form a Fluorescent Ternary Complex with Singular Symmetric Interfaces. J.Mol.Biol., 425, 2013
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4K3D
| Crystal structure of bovine antibody BLV1H12 with ultralong CDR H3 | 分子名称: | BOVINE ANTIBODY WITH ULTRALONG CDR H3, HEAVY CHAIN, LIGHT CHAIN, ... | 著者 | Ekiert, D.C, Wang, F, Wilson, I.A. | 登録日 | 2013-04-10 | 公開日 | 2013-06-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Reshaping antibody diversity. Cell(Cambridge,Mass.), 153, 2013
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