4RQQ

Crystal structure of human Fab PGDM1400, a broadly reactive and potent HIV-1 neutralizing antibody

Summary for 4RQQ

Entry DOI	10.2210/pdb4rqq/pdb
Related	3U1S
Descriptor	Human anti-HIV-1 antibody PGDM1400 light chain, Human anti-HIV-1 antibody PGDM1400 heavy chain (2 entities in total)
Functional Keywords	igg, anti-hiv-1 antibody, hiv-1 env trimer, immune system
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	151600.06
Authors	Julien, J.-P.,Wilson, I.A. (deposition date: 2014-11-04, release date: 2014-11-19, Last modification date: 2023-12-06)
Primary citation	Sok, D.,van Gils, M.J.,Pauthner, M.,Julien, J.P.,Saye-Francisco, K.L.,Hsueh, J.,Briney, B.,Lee, J.H.,Le, K.M.,Lee, P.S.,Hua, Y.,Seaman, M.S.,Moore, J.P.,Ward, A.B.,Wilson, I.A.,Sanders, R.W.,Burton, D.R. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proc.Natl.Acad.Sci.USA, 111:17624-17629, 2014 Cited by PubMed: 25422458 DOI: 10.1073/pnas.1415789111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation