4M6L

Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid

Summary for 4M6L

Entry DOI	10.2210/pdb4m6l/pdb
Related	4M6J 4M6K
Descriptor	Dihydrofolate reductase, N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	rossmann fold, nadph binding, folate binding, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22917.90
Authors	Bhabha, G.,Ekiert, D.C.,Wright, P.E.,Wilson, I.A. (deposition date: 2013-08-09, release date: 2013-09-25, Last modification date: 2023-09-20)
Primary citation	Bhabha, G.,Ekiert, D.C.,Jennewein, M.,Zmasek, C.M.,Tuttle, L.M.,Kroon, G.,Dyson, H.J.,Godzik, A.,Wilson, I.A.,Wright, P.E. Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20:1243-1249, 2013 Cited by PubMed: 24077226 DOI: 10.1038/nsmb.2676 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation