4RBP

Crystal structure of HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomanose

Summary for 4RBP

Entry DOI	10.2210/pdb4rbp/pdb
Related	1OM3 1OP3 1OP5 1ZLS 1ZLU 1ZLV 1ZLW 2OQJ 3OAU 3OAY 3OAZ 3OB0
Descriptor	Fab 2G12 light chain, Fab 2G12 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-5)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, ... (5 entities in total)
Functional Keywords	immunoglobulin fold, hiv neutralizing, hiv-1 gp120, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	96929.81
Authors	Stanfield, R.L.,Wilson, I.A.,De Castro, C.,Marzaioli, A.M.,Pantophlet, R. (deposition date: 2014-09-12, release date: 2014-11-26, Last modification date: 2023-09-20)
Primary citation	Stanfield, R.L.,De Castro, C.,Marzaioli, A.M.,Wilson, I.A.,Pantophlet, R. Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose. Glycobiology, 25:412-419, 2015 Cited by PubMed: 25380763 DOI: 10.1093/glycob/cwu123 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation