9AUL
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![BU of 9aul by Molmil](/molmil-images/mine/9aul) | Structure of SARS-CoV-2 Mpro mutant (A173V,T304I)) in complex with Nirmatrelvir (PF-07321332) | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | Deposit date: | 2024-02-29 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.421 Å) | Cite: | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8WSS
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![BU of 8wss by Molmil](/molmil-images/mine/8wss) | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | Deposit date: | 2023-10-17 | Release date: | 2024-06-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discov, 10, 2024
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8X2P
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![BU of 8x2p by Molmil](/molmil-images/mine/8x2p) | The Crystal Structure of LCK from Biortus. | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, TETRAETHYLENE GLYCOL, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y. | Deposit date: | 2023-11-10 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The Crystal Structure of LCK from Biortus. To Be Published
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9B8Y
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![BU of 9b8y by Molmil](/molmil-images/mine/9b8y) | |
8YIF
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![BU of 8yif by Molmil](/molmil-images/mine/8yif) | Crystal structure of GH13_30 alpha-glucosidase CmmB in complex with acarviosin | Descriptor: | Acarviosin, Alpha-glucosidase | Authors: | Saburi, W, Tagami, T, Yu, J, Ose, T, Yao, M, Mori, H. | Deposit date: | 2024-02-29 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular mechanism for the substrate specificity of Arthrobacter globiformis M6 alpha-glucosidase CmmB, belonging to glycoside hydrolase family 13 subfamily 30 Food Biosci, 61, 2024
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9B8X
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8X7A
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![BU of 8x7a by Molmil](/molmil-images/mine/8x7a) | Treprostinil bound Prostacyclin Receptor G protein complex | Descriptor: | 2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | Deposit date: | 2023-11-23 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.56 Å) | Cite: | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs. Sci Adv, 10, 2024
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9AUK
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![BU of 9auk by Molmil](/molmil-images/mine/9auk) | Structure of SARS-CoV-2 Mpro mutant (A173V) in complex with Nirmatrelvir (PF-07321332) | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | Deposit date: | 2024-02-29 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8X2Q
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![BU of 8x2q by Molmil](/molmil-images/mine/8x2q) | The Crystal Structure of APC from Biortus. | Descriptor: | 1,2-ETHANEDIOL, Adenomatous polyposis coli protein | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Bao, C. | Deposit date: | 2023-11-10 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of APC from Biortus. To Be Published
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8WY0
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![BU of 8wy0 by Molmil](/molmil-images/mine/8wy0) | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | Deposit date: | 2023-10-30 | Release date: | 2024-05-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
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8XQD
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8WOM
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![BU of 8wom by Molmil](/molmil-images/mine/8wom) | Structure of the wild-type Arabidopsis ABCB19 in the brassinolide-bound state | Descriptor: | ABC transporter B family member 19, Brassinolide | Authors: | Ying, W, Wei, H, Liu, X, Sun, L. | Deposit date: | 2023-10-07 | Release date: | 2024-03-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
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8WYI
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![BU of 8wyi by Molmil](/molmil-images/mine/8wyi) | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | Descriptor: | Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | Deposit date: | 2023-10-31 | Release date: | 2024-05-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
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8X5Z
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![BU of 8x5z by Molmil](/molmil-images/mine/8x5z) | |
8YHI
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![BU of 8yhi by Molmil](/molmil-images/mine/8yhi) | The Crystal Structure of SHP1 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Shen, Z. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The Crystal Structure of SHP1 from Biortus. To Be Published
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8XPG
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![BU of 8xpg by Molmil](/molmil-images/mine/8xpg) | The Crystal Structure of polo box domain of Plk4 from Biortus. | Descriptor: | SULFATE ION, Serine/threonine-protein kinase PLK4 | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Zhang, B. | Deposit date: | 2024-01-03 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Crystal Structure of polo box domain of Plk4 from Biortus. To Be Published
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8YGZ
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![BU of 8ygz by Molmil](/molmil-images/mine/8ygz) | The Crystal Structure of TGF beta R2 kinase domain from Biortus. | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, TGF-beta receptor type-2 | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | Deposit date: | 2024-02-27 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of TGF beta R2 kinase domain from Biortus. To Be Published
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8XPX
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![BU of 8xpx by Molmil](/molmil-images/mine/8xpx) | The Crystal Structure of PARP12 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Qi, J, Shen, Z. | Deposit date: | 2024-01-04 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The Crystal Structure of PARP12 from Biortus. To Be Published
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5E2L
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![BU of 5e2l by Molmil](/molmil-images/mine/5e2l) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with D-phenylalanine | Descriptor: | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, CHLORIDE ION, D-PHENYLALANINE, ... | Authors: | Reichau, S, Jiao, W, Parker, E.J. | Deposit date: | 2015-10-01 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids. Plos One, 11, 2016
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8XGR
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![BU of 8xgr by Molmil](/molmil-images/mine/8xgr) | ETB-eGt complex bound to endothelin-1 | Descriptor: | Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ... | Authors: | Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O. | Deposit date: | 2023-12-15 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application. Biochem.Biophys.Res.Commun., 693, 2024
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8WXE
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![BU of 8wxe by Molmil](/molmil-images/mine/8wxe) | Vgamma5Vdelta1 EH TCR-CD3 complex | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1, ... | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | Deposit date: | 2023-10-28 | Release date: | 2024-05-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
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9B6G
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![BU of 9b6g by Molmil](/molmil-images/mine/9b6g) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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8X87
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9B6I
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![BU of 9b6i by Molmil](/molmil-images/mine/9b6i) | Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014 | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9BHN
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![BU of 9bhn by Molmil](/molmil-images/mine/9bhn) | |