9B8Y

Cryo-EM structure of the human TRPM4 channel in complex with calcium and decavanadate at 37 degrees Celsius

Summary for 9B8Y

Entry DOI	10.2210/pdb9b8y/pdb
EMDB information	44362
Descriptor	Transient receptor potential cation channel subfamily M member 4, CALCIUM ION, DECAVANADATE (3 entities in total)
Functional Keywords	ion channel, trp channel, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	541976.15
Authors	Hu, J.,Lu, W.,Du, J. (deposition date: 2024-04-01, release date: 2024-05-15, Last modification date: 2024-05-29)
Primary citation	Hu, J.,Park, S.J.,Walter, T.,Orozco, I.J.,O'Dea, G.,Ye, X.,Du, J.,Lu, W. Physiological temperature drives TRPM4 ligand recognition and gating. Nature, 2024 Cited by PubMed: 38750366 DOI: 10.1038/s41586-024-07436-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation