5UBK
 
 | | Inactive S1A/N269D-cpPvdQ mutant in complex with the pyoverdine precursor PVDIq reveals a specific binding pocket for the D-Tyr of this substrate | | 分子名称: | Acyl-homoserine lactone acylase PvdQ, N-[(1R)-1-{(6S)-6-[(2-amino-2-oxoethyl)carbamoyl]-1,4,5,6-tetrahydropyrimidin-2-yl}-2-(4-hydroxyphenyl)ethyl]-N~2~-tetradecanoyl-L-glutamine | | 著者 | Mascarenhas, R, Catlin, D, Wu, R, Clevenger, K, Fast, W, Liu, D. | | 登録日 | 2016-12-20 | | 公開日 | 2017-03-01 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Circular Permutation Reveals a Chromophore Precursor Binding Pocket of the Siderophore Tailoring Enzyme PvdQ
To Be Published
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4TQU
 | | Crystal structure of a bacterial ABC transporter involved in the import of the acidic polysaccharide alginate | | 分子名称: | 4-deoxy-alpha-L-erythro-hex-4-enopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid, AlgM1, AlgM2, ... | | 著者 | Maruyama, Y, Itoh, T, Kaneko, A, Nishitani, Y, Mikami, B, Hashimoto, W, Murata, K. | | 登録日 | 2014-06-12 | | 公開日 | 2015-07-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.204 Å) | | 主引用文献 | Structure of a Bacterial ABC Transporter Involved in the Import of an Acidic Polysaccharide Alginate
Structure, 23, 2015
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2HXU
 | | Crystal structure of K220A mutant of L-Fuconate Dehydratase from Xanthomonas campestris liganded with Mg++ and L-fuconate | | 分子名称: | 6-deoxy-L-galactonic acid, L-fuconate dehydratase, MAGNESIUM ION, ... | | 著者 | Fedorov, A.A, Fedorov, E.V, Yew, W.S, Rakus, J.F, Gerlt, J.A, Almo, S.C. | | 登録日 | 2006-08-03 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Evolution of Enzymatic Activities in the Enolase Superfamily: l-Fuconate Dehydratase from Xanthomonas campestris.
Biochemistry, 45, 2006
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3BBZ
 | | Structure of the nucleocapsid-binding domain from the mumps virus phosphoprotein | | 分子名称: | BROMIDE ION, FORMIC ACID, P protein | | 著者 | Kingston, R.L, Gay, L.S, Baase, W.S, Matthews, B.W. | | 登録日 | 2007-11-11 | | 公開日 | 2008-05-27 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of the nucleocapsid-binding domain from the mumps virus polymerase; an example of protein folding induced by crystallization
J.Mol.Biol., 379, 2008
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4TS2
 | | Crystal structure of the Spinach RNA aptamer in complex with DFHBI, magnesium ions | | 分子名称: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, MAGNESIUM ION, POTASSIUM ION, ... | | 著者 | Warner, K.D, Chen, M.C, Song, W, Strack, R.L, Thorn, A, Jaffrey, S.R, Ferre-D'Amare, A.R. | | 登録日 | 2014-06-18 | | 公開日 | 2014-07-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.884 Å) | | 主引用文献 | Structural basis for activity of highly efficient RNA mimics of green fluorescent protein.
Nat.Struct.Mol.Biol., 21, 2014
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3K3S
 | | Crystal structure of altronate hydrolase (fragment 1-84) from Shigella Flexneri. | | 分子名称: | ACETATE ION, Altronate hydrolase, CHLORIDE ION, ... | | 著者 | Hou, J, Chruszcz, M, Xu, X, Le, B, Zimmerman, M.D, Savchenko, A, Edwards, A.M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2009-10-04 | | 公開日 | 2009-10-27 | | 最終更新日 | 2022-04-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal structure of altronate hydrolase (fragment 1-84) from Shigella Flexneri.
To be Published
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6GX5
 | | Narrow Pick Filament from Pick's disease brain | | 分子名称: | Microtubule-associated protein tau | | 著者 | Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2018-06-26 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature, 561, 2018
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6BL2
 | | Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd15 | | 分子名称: | 3-[(6aS,7S,9S,10aS)-9-cyano-7-methyl-8-oxo-2-(phenylamino)-6,6a,7,8,9,10-hexahydrobenzo[h]quinazolin-10a(5H)-yl]benzoic acid, CALCIUM ION, ISOCITRIC ACID, ... | | 著者 | Jakob, C.G, Qiu, W. | | 登録日 | 2017-11-09 | | 公開日 | 2018-07-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
J. Med. Chem., 61, 2018
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2ODD
 | | Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor | | 分子名称: | Protein CBFA2T1, SMRT, ZINC ION | | 著者 | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | | 登録日 | 2006-12-22 | | 公開日 | 2007-06-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer Cell, 11, 2007
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3KLL
 | | Crystal structure of Lactobacillus reuteri N-terminally truncated glucansucrase GTF180-maltose complex | | 分子名称: | CALCIUM ION, GLYCEROL, Glucansucrase, ... | | 著者 | Vujicic-Zagar, A, Pijning, T, Kralj, S, Eeuwema, W, Dijkhuizen, L, Dijkstra, B.W. | | 登録日 | 2009-11-08 | | 公開日 | 2010-11-03 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes
Proc.Natl.Acad.Sci.USA, 107, 2010
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4TO0
 | | Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP-dCTP complex | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | 著者 | Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. | | 登録日 | 2014-06-05 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis of cellular dNTP regulation by SAMHD1.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5JN9
 | | Crystal structure for the complex of human carbonic anhydrase IV and ethoxyzolamide | | 分子名称: | 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ACETATE ION, Carbonic anhydrase 4, ... | | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | | 登録日 | 2016-04-29 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
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5U4W
 | | Cryo-EM Structure of Immature Zika Virus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, E protein, M protein, ... | | 著者 | Mangala Prasad, V, Miller, A.S, Klose, T, Sirohi, D, Buda, G, Jiang, W, Kuhn, R.J, Rossmann, M.G. | | 登録日 | 2016-12-06 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (9.1 Å) | | 主引用文献 | Structure of the immature Zika virus at 9 angstrom resolution.
Nat. Struct. Mol. Biol., 24, 2017
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4P8U
 | | The crystal structures of YKL-39 in the absence of chitooligosaccharides was solved to resolutions of 2.4 angstrom | | 分子名称: | Chitinase-3-like protein 2, DI(HYDROXYETHYL)ETHER, SULFATE ION | | 著者 | Suginta, W, Ranok, A, Robinson, R.C, Wongsantichon, J. | | 登録日 | 2014-04-01 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and Thermodynamic Insights into Chitooligosaccharide Binding to Human Cartilage Chitinase 3-like Protein 2 (CHI3L2 or YKL-39).
J.Biol.Chem., 290, 2015
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5TSU
 | | Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine | | 分子名称: | CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ... | | 著者 | Yan, W, Zhang, Y. | | 登録日 | 2016-10-31 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
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6C8K
 | | RNA-activated 2-AIpG monomer complex, 30 min soaking | | 分子名称: | 2-amino-1-[(R)-{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]-3-[(S)-{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]-1H-imidazol-3-ium, MAGNESIUM ION, RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') | | 著者 | Zhang, W, Szostak, J.W. | | 登録日 | 2018-01-24 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.259 Å) | | 主引用文献 | Crystallographic observation of nonenzymatic RNA primer extension.
Elife, 7, 2018
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6C8O
 | | RNA-activated 2-AIpG monomer, 3h soaking | | 分子名称: | 5'-O-[(R)-(2-amino-1H-imidazol-1-yl)(hydroxy)phosphoryl]guanosine, MAGNESIUM ION, RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') | | 著者 | Zhang, W, Szostak, J.W. | | 登録日 | 2018-01-25 | | 公開日 | 2018-05-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystallographic observation of nonenzymatic RNA primer extension.
Elife, 7, 2018
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3KD3
 | | Crystal structure of a phosphoserine phosphohydrolase-like protein from Francisella tularensis subsp. tularensis SCHU S4 | | 分子名称: | GLYCEROL, MAGNESIUM ION, Phosphoserine phosphohydrolase-like protein | | 著者 | Nocek, B, Zhou, M, Peterson, S, Anderson, W, Joachimiak, A, CSGID, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2009-10-22 | | 公開日 | 2009-12-15 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of a phosphoserine phosphohydrolase-like protein from Francisella tularensis subsp. tularensis SCHUS4
TO BE PUBLISHED
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6GHG
 | | Variable heavy - variable light domain and Fab-arm CrossMabs with charged residue exchanges | | 分子名称: | Fab heavy chain, Fab light chain, HEXAETHYLENE GLYCOL, ... | | 著者 | Regula, J, Imhof-Jung, S, Molhoj, M, Benz, J, Ehler, A, Bujotzek, A, Schaefer, W, Klein, C. | | 登録日 | 2018-05-07 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.
Protein Eng. Des. Sel., 31, 2018
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4PMN
 | | Crystal structure of the Mycobacterium tuberculosis Tat-secreted protein Rv2525c in complex with MES (monoclinic crystal form I) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, SULFATE ION, ... | | 著者 | Bellinzoni, M, Haouz, A, Shepard, W, Alzari, P.M. | | 登録日 | 2014-05-22 | | 公開日 | 2014-10-08 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
J.Struct.Biol., 188, 2014
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7E59
 | | interferon-inducible anti-viral protein truncated | | 分子名称: | Guanylate-binding protein 5 | | 著者 | Cui, W, Wang, W, Chen, C, Slater, B, Xiong, Y, Ji, X.Y, Yang, H.T. | | 登録日 | 2021-02-18 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6BKZ
 | | Novel Modes of Inhibition of Wild-Type IDH1: Non-equivalent Allosteric Inhibition with Cmpd3 | | 分子名称: | (7R)-1-[(4-fluorophenyl)methyl]-N-{3-[(1R)-1-hydroxyethyl]phenyl}-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Jakob, C.G, Qiu, W. | | 登録日 | 2017-11-09 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
J. Med. Chem., 61, 2018
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2NS7
 | | How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor | | 分子名称: | Tetracycline repressor protein | | 著者 | Luckner, S.R, Klotzsche, M, Berens, C, Hillen, W, Muller, Y.A. | | 登録日 | 2006-11-03 | | 公開日 | 2007-07-24 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor
J.Mol.Biol., 368, 2007
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6C8I
 | | RNA-activated 2-AIpG monomer complex, 5 min soaking | | 分子名称: | 5'-O-[(R)-(2-amino-1H-imidazol-1-yl)(hydroxy)phosphoryl]guanosine, MAGNESIUM ION, RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') | | 著者 | Zhang, W, Szostak, J.W. | | 登録日 | 2018-01-24 | | 公開日 | 2018-05-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Crystallographic observation of nonenzymatic RNA primer extension.
Elife, 7, 2018
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7E58
 | | interferon-inducible anti-viral protein 2 | | 分子名称: | Guanylate-binding protein 2 | | 著者 | Cui, W, Wang, W, Chen, C, Slater, B, Xiong, Y, Ji, X.Y, Yang, H.T. | | 登録日 | 2021-02-18 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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