6GHG
Variable heavy - variable light domain and Fab-arm CrossMabs with charged residue exchanges
Summary for 6GHG
Entry DOI | 10.2210/pdb6ghg/pdb |
Descriptor | Fab heavy chain, Fab light chain, SODIUM ION, ... (5 entities in total) |
Functional Keywords | antibody, fab fragment, dp47, ang2, vegf, crossmab, charge variants, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 93011.25 |
Authors | Regula, J.,Imhof-Jung, S.,Molhoj, M.,Benz, J.,Ehler, A.,Bujotzek, A.,Schaefer, W.,Klein, C. (deposition date: 2018-05-07, release date: 2018-09-12, Last modification date: 2018-12-05) |
Primary citation | Regula, J.T.,Imhof-Jung, S.,Molhoj, M.,Benz, J.,Ehler, A.,Bujotzek, A.,Schaefer, W.,Klein, C. Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly. Protein Eng. Des. Sel., 31:289-299, 2018 Cited by PubMed: 30169707DOI: 10.1093/protein/gzy021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
Download full validation report