6GHG

Variable heavy - variable light domain and Fab-arm CrossMabs with charged residue exchanges

Summary for 6GHG

• Entry DOI: 10.2210/pdb6ghg/pdb
• Descriptor: Fab heavy chain, Fab light chain, SODIUM ION, ... (5 entities in total)
• Functional Keywords: antibody, fab fragment, dp47, ang2, vegf, crossmab, charge variants, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 93011.25

Authors

Regula, J.,Imhof-Jung, S.,Molhoj, M.,Benz, J.,Ehler, A.,Bujotzek, A.,Schaefer, W.,Klein, C. (deposition date: 2018-05-07, release date: 2018-09-12, Last modification date: 2018-12-05)

• Primary citation: Regula, J.T.,Imhof-Jung, S.,Molhoj, M.,Benz, J.,Ehler, A.,Bujotzek, A.,Schaefer, W.,Klein, C.; Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.; Protein Eng. Des. Sel., 31:289-299, 2018; PubMed: 30169707; DOI: 10.1093/protein/gzy021

Experimental method

X-RAY DIFFRACTION (1.88 Å)