6QD6
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![BU of 6qd6 by Molmil](/molmil-images/mine/6qd6) | Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 | 分子名称: | CHLORIDE ION, Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207 | 著者 | Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkonig, A, Zogg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J. | 登録日 | 2018-12-31 | 公開日 | 2019-12-18 | 最終更新日 | 2021-01-13 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM Nat.Methods, 18, 2021
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1SGD
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![BU of 1sgd by Molmil](/molmil-images/mine/1sgd) | ASP 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5 | 分子名称: | Ovomucoid, PHOSPHATE ION, Streptogrisin B | 著者 | Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G. | 登録日 | 1999-03-25 | 公開日 | 2003-08-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pH's To be Published
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6PUS
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![BU of 6pus by Molmil](/molmil-images/mine/6pus) | Human TRPM2 bound to ADPR and calcium | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | 著者 | Du, J, Lu, W, Huang, Y. | 登録日 | 2019-07-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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1LY3
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![BU of 1ly3 by Molmil](/molmil-images/mine/1ly3) | ANALYSIS OF QUINAZOLINE AND PYRIDOPYRIMIDINE N9-C10 REVERSED BRIDGE ANTIFOLATES IN COMPLEX WITH NADP+ AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE | 分子名称: | 2,4-DIAMINO-6-[N-(2',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]QUINAZOLINE, DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Queener, S.F, Gangjee, A. | 登録日 | 2002-06-06 | 公開日 | 2002-08-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr.,Sect.D, 58, 2002
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6W5D
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![BU of 6w5d by Molmil](/molmil-images/mine/6w5d) | Crystal Structure of Fab RSB1 | 分子名称: | RSB1 Fab Heavy Chain, RSB1 Fab Light Chain | 著者 | Harshbarger, W, Chandramouli, S, Malito, M. | 登録日 | 2020-03-13 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F. Plos Pathog., 16, 2020
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6W8T
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![BU of 6w8t by Molmil](/molmil-images/mine/6w8t) | Crystal structure of metacaspase 4 from Arabidopsis (microcrystals treated with calcium) | 分子名称: | Metacaspase-4, SULFATE ION | 著者 | Zhu, P, Yu, X.H, Wang, C, Zhang, Q, Liu, W, McSweeney, S, Shanklin, J, Lam, E, Liu, Q. | 登録日 | 2020-03-21 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for Ca2+-dependent activation of a plant metacaspase. Nat Commun, 11, 2020
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6Q06
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![BU of 6q06 by Molmil](/molmil-images/mine/6q06) | MERS-CoV S structure in complex with 2,3-sialyl-N-acetyl-lactosamine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ... | 著者 | Park, Y.J, Walls, A.C, Wang, Z, Sauer, M, Li, W, Tortorici, M.A, Bosch, B.J, DiMaio, F.D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2019-08-01 | 公開日 | 2019-12-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. Nat.Struct.Mol.Biol., 26, 2019
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6WBK
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421P
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![BU of 421p by Molmil](/molmil-images/mine/421p) | THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | 分子名称: | H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Krengel, U, John, J, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. | 登録日 | 1991-06-06 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
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1QFR
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![BU of 1qfr by Molmil](/molmil-images/mine/1qfr) | NMR SOLUTION STRUCTURE OF PHOSPHOCARRIER PROTEIN HPR FROM ENTEROCOCCUS FAECALIS | 分子名称: | PHOSPHOCARRIER PROTEIN HPR | 著者 | Maurer, T, Doeker, R, Goerler, A, Hengstenberg, W, Kalbitzer, H.R. | 登録日 | 1999-04-13 | 公開日 | 2001-02-28 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Three-dimensional structure of the histidine-containing phosphocarrier protein (HPr) from Enterococcus faecalis in solution. Eur.J.Biochem., 268, 2001
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6VJV
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![BU of 6vjv by Molmil](/molmil-images/mine/6vjv) | Crystal structure of the Prochlorococcus phage (myovirus P-SSM2) ferredoxin at 1.6 Angstroms | 分子名称: | ACETATE ION, FE2/S2 (INORGANIC) CLUSTER, Ferredoxin, ... | 著者 | Olmos Jr, J.L, Campbell, I.J, Miller, M.D, Xu, W, Kahanda, D, Atkinson, J.T, Sparks, N, Bennett, G.N, Silberg, J.J, Phillips Jr, G.N. | 登録日 | 2020-01-17 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Prochlorococcusphage ferredoxin: structural characterization and electron transfer to cyanobacterial sulfite reductases. J.Biol.Chem., 295, 2020
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6OLF
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4B2Q
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6VIX
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![BU of 6vix by Molmil](/molmil-images/mine/6vix) | BRD4_Bromodomain2 complex with pyrrolopyridone compound 18 | 分子名称: | 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 | 著者 | Longenecker, K.L, Park, C.H, Qiu, W. | 登録日 | 2020-01-14 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.116 Å) | 主引用文献 | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
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6OFB
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![BU of 6ofb by Molmil](/molmil-images/mine/6ofb) | Crystal structure of human glutamine-dependent NAD+ synthetase complexed with NaAD+, AMP, pyrophosphate, and Mg2+ | 分子名称: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, Glutamine-dependent NAD(+) synthetase, ... | 著者 | Chuenchor, W, Doukov, T.I, Gerratana, B. | 登録日 | 2019-03-28 | 公開日 | 2020-01-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+synthetases. Nat Commun, 11, 2020
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3RTP
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![BU of 3rtp by Molmil](/molmil-images/mine/3rtp) | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration | 分子名称: | Mitogen-activated protein kinase 10, N-[4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | 著者 | Bowers, S, Truong, A.P, Neitz, R.J, Hom, R.K, Sealy, J.M, Probst, G.D, Quincy, Q, Peterson, B, Chan, W, Galemmo Jr, R.A, Konradi, A.W, Sham, H.L, Pan, H, Lin, M, Yao, N, Artis, D.R, Zhang, H, Chen, L, Dryer, M, Samant, B, Zmolek, W, Wong, K, Lorentzen, C, Goldbach, E, Tonn, G, Quinn, K.P, Sauer, J, Wright, S, Powell, K, Ruslim, L, Ren, Z, Bard, F, Yednock, T.A, Griswold-Prenne, I. | 登録日 | 2011-05-03 | 公開日 | 2013-05-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. Bioorg.Med.Chem.Lett., 21, 2011
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6W9U
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![BU of 6w9u by Molmil](/molmil-images/mine/6w9u) | Structure of human MAIT A-F7 TCR in complex with patient MR1-R9H-Ac-6-FP | 分子名称: | 1-[[6-(1-$l^{1}-oxidanylethyl)-4-$l^{3}-oxidanylidene-2,3,6,8~{a}-tetrahydropteridin-2-yl]-$l^{2}-azanyl]ethanone, Beta-2-microglobulin, CHLORIDE ION, ... | 著者 | Awad, W, Rossjohn, J. | 登録日 | 2020-03-23 | 公開日 | 2020-08-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1 . Sci Immunol, 5, 2020
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6VQW
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![BU of 6vqw by Molmil](/molmil-images/mine/6vqw) | Type I-F CRISPR-Csy complex with its inhibitor AcrF8 | 分子名称: | AcrF8, CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, ... | 著者 | Zhang, K, Li, S, Pintilie, G, Zhu, Y, Huang, Z, Chiu, W. | 登録日 | 2020-02-06 | 公開日 | 2020-03-11 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
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6OM0
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6WBF
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![BU of 6wbf by Molmil](/molmil-images/mine/6wbf) | Cryo-EM structure of wild type human Pannexin 1 channel | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Lu, W, Du, J, Ruan, Z. | 登録日 | 2020-03-26 | 公開日 | 2020-06-03 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature, 584, 2020
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6O8A
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![BU of 6o8a by Molmil](/molmil-images/mine/6o8a) | Thaumatin native-SAD structure determined at 5 keV from microcrystals | 分子名称: | L(+)-TARTARIC ACID, Thaumatin-1 | 著者 | Guo, G, Zhu, P, Fuchs, M.R, Shi, W, Andi, B, Gao, Y, Hendrickson, W.A, McSweeney, S, Liu, Q. | 登録日 | 2019-03-09 | 公開日 | 2019-05-08 | 最終更新日 | 2019-12-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Synchrotron microcrystal native-SAD phasing at a low energy. Iucrj, 6, 2019
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1UWD
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![BU of 1uwd by Molmil](/molmil-images/mine/1uwd) | NMR STRUCTURE OF A PROTEIN WITH UNKNOWN FUNCTION FROM THERMOTOGA MARITIMA (TM0487), WHICH BELONGS TO THE DUF59 FAMILY. | 分子名称: | HYPOTHETICAL PROTEIN TM0487 | 著者 | Almeida, M.S, Peti, W, Herrmann, T, Wuthrich, K. | 登録日 | 2004-02-03 | 公開日 | 2004-12-14 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Structure of the Conserved Hypothetical Protein Tm0487 from Thermotoga Maritima: Implications for 216 Homologous Duf59 Proteins. Protein Sci., 14, 2005
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6W9V
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2JAE
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![BU of 2jae by Molmil](/molmil-images/mine/2jae) | The structure of L-amino acid oxidase from Rhodococcus opacus in the unbound state | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, L-AMINO ACID OXIDASE | 著者 | Faust, A, Niefind, K, Hummel, W, Schomburg, D. | 登録日 | 2006-11-27 | 公開日 | 2007-01-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | The Structure of a Bacterial L-Amino Acid Oxidase from Rhodococcus Opacus Gives New Evidence for the Hydride Mechanism for Dehydrogenation. J.Mol.Biol., 367, 2007
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6WBG
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![BU of 6wbg by Molmil](/molmil-images/mine/6wbg) | Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7 | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Lu, W, Du, J, Ruan, Z. | 登録日 | 2020-03-26 | 公開日 | 2020-06-03 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature, 584, 2020
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