4UEL
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![BU of 4uel by Molmil](/molmil-images/mine/4uel) | UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain | Descriptor: | POLYUBIQUITIN-B, PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 | Authors: | Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K. | Deposit date: | 2014-12-18 | Release date: | 2015-03-04 | Last modified: | 2019-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G. Mol.Cell, 57, 2015
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4UEM
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![BU of 4uem by Molmil](/molmil-images/mine/4uem) | UCH-L5 in complex with the RPN13 DEUBAD domain | Descriptor: | PROTEASOMAL UBIQUITIN RECEPTOR ADRM1, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 | Authors: | Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K. | Deposit date: | 2014-12-18 | Release date: | 2015-03-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G. Mol.Cell, 57, 2015
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4UF5
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![BU of 4uf5 by Molmil](/molmil-images/mine/4uf5) | Crystal structure of UCH-L5 in complex with inhibitory fragment of INO80G | Descriptor: | NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 | Authors: | Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K. | Deposit date: | 2014-12-23 | Release date: | 2015-03-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G. Mol.Cell, 57, 2015
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4UF6
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![BU of 4uf6 by Molmil](/molmil-images/mine/4uf6) | UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G | Descriptor: | NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, POLYUBIQUITIN-B, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 | Authors: | Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K. | Deposit date: | 2014-12-23 | Release date: | 2015-03-04 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.69 Å) | Cite: | Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G. Mol.Cell, 57, 2015
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7FDY
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![BU of 7fdy by Molmil](/molmil-images/mine/7fdy) | Structure of OmpF1 | Descriptor: | Porin OmpF, ZINC ION | Authors: | Jeong, W.J, Song, W.J. | Deposit date: | 2021-07-18 | Release date: | 2022-11-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Design and directed evolution of noncanonical beta-stereoselective metalloglycosidases. Nat Commun, 13, 2022
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7FF7
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![BU of 7ff7 by Molmil](/molmil-images/mine/7ff7) | Structure of OmpF2 | Descriptor: | Outer membrane protein F, ZINC ION | Authors: | Jeong, W.J, Song, W.J. | Deposit date: | 2021-07-22 | Release date: | 2022-11-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Design and directed evolution of noncanonical beta-stereoselective metalloglycosidases. Nat Commun, 13, 2022
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4EKF
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![BU of 4ekf by Molmil](/molmil-images/mine/4ekf) | |
2BCA
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![BU of 2bca by Molmil](/molmil-images/mine/2bca) | |
2BCB
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![BU of 2bcb by Molmil](/molmil-images/mine/2bcb) | |
7RZH
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![BU of 7rzh by Molmil](/molmil-images/mine/7rzh) | Insulin Degrading Enzyme O/O | Descriptor: | Cysteine-free Insulin-degrading enzyme | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | Deposit date: | 2021-08-27 | Release date: | 2022-08-31 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZI
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![BU of 7rzi by Molmil](/molmil-images/mine/7rzi) | Insulin Degrading Enzyme pC/pC | Descriptor: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | Deposit date: | 2021-08-27 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZE
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![BU of 7rze by Molmil](/molmil-images/mine/7rze) | Insulin Degrading Enzyme pO/pC | Descriptor: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | Deposit date: | 2021-08-27 | Release date: | 2022-08-31 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZF
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![BU of 7rzf by Molmil](/molmil-images/mine/7rzf) | Insulin Degrading Enzyme O/pC | Descriptor: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | Deposit date: | 2021-08-27 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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7RZG
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![BU of 7rzg by Molmil](/molmil-images/mine/7rzg) | Insulin Degrading Enzyme O/pO | Descriptor: | Cysteine-free Insulin-degrading enzyme | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | Deposit date: | 2021-08-27 | Release date: | 2022-08-31 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
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2TPT
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![BU of 2tpt by Molmil](/molmil-images/mine/2tpt) | STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE | Descriptor: | SULFATE ION, THYMIDINE PHOSPHORYLASE | Authors: | Pugmire, M.J, Cook, W.J, Jasanoff, A, Walter, M.R, Ealick, S.E. | Deposit date: | 1997-11-24 | Release date: | 1999-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase. J.Mol.Biol., 281, 1998
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2SAS
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![BU of 2sas by Molmil](/molmil-images/mine/2sas) | |
7TL3
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![BU of 7tl3 by Molmil](/molmil-images/mine/7tl3) | Crystal Structure of Yeast p58C Multi-Tyrosine Mutant 5YF431 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA primase large subunit, IRON/SULFUR CLUSTER | Authors: | Blee, A.M, Salay, L.E, Chazin, W.J. | Deposit date: | 2022-01-18 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.066 Å) | Cite: | Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase. Biochemistry, 61, 2022
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7TL4
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![BU of 7tl4 by Molmil](/molmil-images/mine/7tl4) | Crystal Structure of Yeast p58C Multi-Tyrosine Mutant 6YF | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA primase large subunit, IRON/SULFUR CLUSTER | Authors: | Blee, A.M, Salay, L.E, Chazin, W.J. | Deposit date: | 2022-01-18 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.805 Å) | Cite: | Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase. Biochemistry, 61, 2022
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7TL2
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![BU of 7tl2 by Molmil](/molmil-images/mine/7tl2) | Crystal Structure of Yeast p58C Multi-Tyrosine Mutant 5YF412 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA primase large subunit, GLYCEROL, ... | Authors: | Blee, A.M, Salay, L.E, Chazin, W.J. | Deposit date: | 2022-01-18 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.529 Å) | Cite: | Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase. Biochemistry, 61, 2022
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3PMG
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![BU of 3pmg by Molmil](/molmil-images/mine/3pmg) | |
5I7M
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![BU of 5i7m by Molmil](/molmil-images/mine/5i7m) | |
5J71
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![BU of 5j71 by Molmil](/molmil-images/mine/5j71) | Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS35 | Descriptor: | 4-({5-[(piperidin-4-yl)amino]-1,3-dihydro-2H-isoindol-2-yl}sulfonyl)benzene-1,3-diol, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, ... | Authors: | Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Wynn, R.M, Chuang, D.T. | Deposit date: | 2016-04-05 | Release date: | 2017-01-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. J. Med. Chem., 60, 2017
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5J8R
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![BU of 5j8r by Molmil](/molmil-images/mine/5j8r) | Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 12 | Authors: | Li, H, Yang, F, Xu, Y.F, Wang, W.J, Xiao, P, Yu, X, Sun, J.P. | Deposit date: | 2016-04-08 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.043 Å) | Cite: | Crystal structure and substrate specificity of PTPN12. Cell Rep, 15, 2016
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1UBQ
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![BU of 1ubq by Molmil](/molmil-images/mine/1ubq) | |
6TXQ
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![BU of 6txq by Molmil](/molmil-images/mine/6txq) | The high resolution structure of the FERM domain and helical linker of human moesin | Descriptor: | ACETATE ION, Moesin | Authors: | Bradshaw, W.J, Katis, V.L, Kelly, J.J, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2020-01-14 | Release date: | 2020-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
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