4UF6

UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G

Summary for 4UF6

DescriptorUBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5, POLYUBIQUITIN-B, NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN (3 entities in total)
Functional Keywordshydrolase, deubiquitinating enzyme
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains12
Total molecular weight215071.43
Authors
Sahtoe, D.D.,Van Dijk, W.J.,El Oualid, F.,Ekkebus, R.,Ovaa, H.,Sixma, T.K. (deposition date: 2014-12-23, release date: 2015-03-04, Last modification date: 2019-04-03)
Primary citation
Sahtoe, D.D.,Van Dijk, W.J.,El Oualid, F.,Ekkebus, R.,Ovaa, H.,Sixma, T.K.
Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G.
Mol.Cell, 57:887-, 2015
PubMed: 25702870 (PDB entries with the same primary citation)
DOI: 10.1016/J.MOLCEL.2014.12.039
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.69 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26790 0.5% 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report