Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4UF6

UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006275	biological_process	regulation of DNA replication
A	0006338	biological_process	chromatin remodeling
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016579	biological_process	protein deubiquitination
A	0031011	cellular_component	Ino80 complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0033044	biological_process	regulation of chromosome organization
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0051726	biological_process	regulation of cell cycle
A	0060382	biological_process	regulation of DNA strand elongation
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070628	molecular_function	proteasome binding
C	0031011	cellular_component	Ino80 complex
D	0003723	molecular_function	RNA binding
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006275	biological_process	regulation of DNA replication
D	0006338	biological_process	chromatin remodeling
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0016579	biological_process	protein deubiquitination
D	0031011	cellular_component	Ino80 complex
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0033044	biological_process	regulation of chromosome organization
D	0045880	biological_process	positive regulation of smoothened signaling pathway
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0051726	biological_process	regulation of cell cycle
D	0060382	biological_process	regulation of DNA strand elongation
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070628	molecular_function	proteasome binding
F	0031011	cellular_component	Ino80 complex
G	0003723	molecular_function	RNA binding
G	0004843	molecular_function	cysteine-type deubiquitinase activity
G	0004866	molecular_function	endopeptidase inhibitor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006275	biological_process	regulation of DNA replication
G	0006338	biological_process	chromatin remodeling
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016579	biological_process	protein deubiquitination
G	0031011	cellular_component	Ino80 complex
G	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0033044	biological_process	regulation of chromosome organization
G	0045880	biological_process	positive regulation of smoothened signaling pathway
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0051726	biological_process	regulation of cell cycle
G	0060382	biological_process	regulation of DNA strand elongation
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070628	molecular_function	proteasome binding
I	0031011	cellular_component	Ino80 complex
J	0003723	molecular_function	RNA binding
J	0004843	molecular_function	cysteine-type deubiquitinase activity
J	0004866	molecular_function	endopeptidase inhibitor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006275	biological_process	regulation of DNA replication
J	0006338	biological_process	chromatin remodeling
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0016579	biological_process	protein deubiquitination
J	0031011	cellular_component	Ino80 complex
J	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0033044	biological_process	regulation of chromosome organization
J	0045880	biological_process	positive regulation of smoothened signaling pathway
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0051726	biological_process	regulation of cell cycle
J	0060382	biological_process	regulation of DNA strand elongation
J	0061136	biological_process	regulation of proteasomal protein catabolic process
J	0070628	molecular_function	proteasome binding
L	0031011	cellular_component	Ino80 complex

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	112
Details	Domain: {"description":"ULD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01394","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Important for enzyme activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9WUP7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)