4UF6

UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000723	biological_process	telomere maintenance
A	0003723	molecular_function	RNA binding
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006310	biological_process	DNA recombination
A	0006338	biological_process	chromatin remodeling
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006974	biological_process	DNA damage response
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016579	biological_process	protein deubiquitination
A	0016787	molecular_function	hydrolase activity
A	0021670	biological_process	lateral ventricle development
A	0030901	biological_process	midbrain development
A	0031011	cellular_component	Ino80 complex
A	0031597	cellular_component	cytosolic proteasome complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0033044	biological_process	regulation of chromosome organization
A	0045739	biological_process	positive regulation of DNA repair
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0048853	biological_process	forebrain morphogenesis
A	0051726	biological_process	regulation of cell cycle
A	0060382	biological_process	regulation of DNA strand elongation
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070628	molecular_function	proteasome binding
A	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
C	0031011	cellular_component	Ino80 complex
D	0000502	cellular_component	proteasome complex
D	0000723	biological_process	telomere maintenance
D	0003723	molecular_function	RNA binding
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006275	biological_process	regulation of DNA replication
D	0006281	biological_process	DNA repair
D	0006282	biological_process	regulation of DNA repair
D	0006310	biological_process	DNA recombination
D	0006338	biological_process	chromatin remodeling
D	0006508	biological_process	proteolysis
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006974	biological_process	DNA damage response
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0016579	biological_process	protein deubiquitination
D	0016787	molecular_function	hydrolase activity
D	0021670	biological_process	lateral ventricle development
D	0030901	biological_process	midbrain development
D	0031011	cellular_component	Ino80 complex
D	0031597	cellular_component	cytosolic proteasome complex
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0033044	biological_process	regulation of chromosome organization
D	0045739	biological_process	positive regulation of DNA repair
D	0045880	biological_process	positive regulation of smoothened signaling pathway
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045995	biological_process	regulation of embryonic development
D	0048853	biological_process	forebrain morphogenesis
D	0051726	biological_process	regulation of cell cycle
D	0060382	biological_process	regulation of DNA strand elongation
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070628	molecular_function	proteasome binding
D	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
F	0031011	cellular_component	Ino80 complex
G	0000502	cellular_component	proteasome complex
G	0000723	biological_process	telomere maintenance
G	0003723	molecular_function	RNA binding
G	0004843	molecular_function	cysteine-type deubiquitinase activity
G	0004866	molecular_function	endopeptidase inhibitor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006275	biological_process	regulation of DNA replication
G	0006281	biological_process	DNA repair
G	0006282	biological_process	regulation of DNA repair
G	0006310	biological_process	DNA recombination
G	0006338	biological_process	chromatin remodeling
G	0006508	biological_process	proteolysis
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006974	biological_process	DNA damage response
G	0008233	molecular_function	peptidase activity
G	0008234	molecular_function	cysteine-type peptidase activity
G	0016579	biological_process	protein deubiquitination
G	0016787	molecular_function	hydrolase activity
G	0021670	biological_process	lateral ventricle development
G	0030901	biological_process	midbrain development
G	0031011	cellular_component	Ino80 complex
G	0031597	cellular_component	cytosolic proteasome complex
G	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0033044	biological_process	regulation of chromosome organization
G	0045739	biological_process	positive regulation of DNA repair
G	0045880	biological_process	positive regulation of smoothened signaling pathway
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045995	biological_process	regulation of embryonic development
G	0048853	biological_process	forebrain morphogenesis
G	0051726	biological_process	regulation of cell cycle
G	0060382	biological_process	regulation of DNA strand elongation
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070628	molecular_function	proteasome binding
G	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
I	0031011	cellular_component	Ino80 complex
J	0000502	cellular_component	proteasome complex
J	0000723	biological_process	telomere maintenance
J	0003723	molecular_function	RNA binding
J	0004843	molecular_function	cysteine-type deubiquitinase activity
J	0004866	molecular_function	endopeptidase inhibitor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006275	biological_process	regulation of DNA replication
J	0006281	biological_process	DNA repair
J	0006282	biological_process	regulation of DNA repair
J	0006310	biological_process	DNA recombination
J	0006338	biological_process	chromatin remodeling
J	0006508	biological_process	proteolysis
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0006974	biological_process	DNA damage response
J	0008233	molecular_function	peptidase activity
J	0008234	molecular_function	cysteine-type peptidase activity
J	0016579	biological_process	protein deubiquitination
J	0016787	molecular_function	hydrolase activity
J	0021670	biological_process	lateral ventricle development
J	0030901	biological_process	midbrain development
J	0031011	cellular_component	Ino80 complex
J	0031597	cellular_component	cytosolic proteasome complex
J	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0033044	biological_process	regulation of chromosome organization
J	0045739	biological_process	positive regulation of DNA repair
J	0045880	biological_process	positive regulation of smoothened signaling pathway
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0045995	biological_process	regulation of embryonic development
J	0048853	biological_process	forebrain morphogenesis
J	0051726	biological_process	regulation of cell cycle
J	0060382	biological_process	regulation of DNA strand elongation
J	0061136	biological_process	regulation of proteasomal protein catabolic process
J	0070628	molecular_function	proteasome binding
J	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
L	0031011	cellular_component	Ino80 complex

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
H	ARG54
H	ARG72
K	ARG54
K	ARG72
B	ARG54
B	ARG72
E	ARG54
E	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68
E	HIS68
H	HIS68
K	HIS68

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
B	SER65
E	SER65
H	SER65
K	SER65

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
B	THR66
E	THR66
H	THR66
K	THR66
G	LYS47
G	HIS289
J	LYS47
J	HIS289

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
B	AYE76
E	AYE76
H	AYE76
K	AYE76

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
B	LYS6
H	LYS6
E	LYS6
K	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
B	AYE76
E	AYE76
H	AYE76
K	AYE76

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
H	LYS11
H	LYS48
K	LYS11
K	LYS48
B	LYS11
B	LYS48
E	LYS11
E	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
B	LYS27
E	LYS27
H	LYS27
K	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
B	LYS29
E	LYS29
H	LYS29
K	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
B	LYS33
E	LYS33
H	LYS33
K	LYS33

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site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
B	LYS63
E	LYS63
H	LYS63
K	LYS63

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