6TXQ
The high resolution structure of the FERM domain and helical linker of human moesin
This is a non-PDB format compatible entry.
Summary for 6TXQ
Entry DOI | 10.2210/pdb6txq/pdb |
Descriptor | Moesin, ACETATE ION (3 entities in total) |
Functional Keywords | pip, ferm domain, alzheimer's disease, cd44, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41200.43 |
Authors | Bradshaw, W.J.,Katis, V.L.,Kelly, J.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-01-14, release date: 2020-01-29, Last modification date: 2024-02-14) |
Primary citation | Du, Y.,Bradshaw, W.J.,Leisner, T.M.,Annor-Gyamfi, J.K.,Qian, K.,Bashore, F.M.,Sikdar, A.,Nwogbo, F.O.,Ivanov, A.A.,Frye, S.V.,Gileadi, O.,Brennan, P.E.,Levey, A.I.,Axtman, A.D.,Pearce, K.H.,Fu, H.,Katis, V.L. Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299:105382-105382, 2023 Cited by PubMed: 37866628DOI: 10.1016/j.jbc.2023.105382 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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