Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 1306 件
1ZHL
DownloadVisualize
BU of 1zhl by Molmil
Crystal structure of HLA-B*3508 presenting 13-mer EBV antigen LPEPLPQGQLTAY
分子名称: Beta-2-microglobulin, EBV-peptide LPEPLPQGQLTAY, HLA class I histocompatibility antigen, ...
著者Tynan, F.E, Borg, N.A, Miles, J.J, Beddoe, T, El-Hassen, D, Silins, S.L, van Zuylen, W.J, Purcell, A.W, Kjer-Nielsen, L, McCluskey, J, Burrows, S.R, Rossjohn, J.
登録日2005-04-26
公開日2005-05-17
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance
J.Biol.Chem., 280, 2005
4ND3
DownloadVisualize
BU of 4nd3 by Molmil
Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (l-lactic acid) and cofactor (b-nicotinamide adenine dinucleotide)
分子名称: (2S)-2-HYDROXYPROPANOIC ACID, GLYCEROL, Lactate dehydrogenase, ...
著者Chattopadhyay, D, Cook, W.J.
登録日2013-10-25
公開日2014-12-17
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Biochemical and structural characterization of Cryptosporidium parvum Lactate dehydrogenase.
Int.J.Biol.Macromol., 74C, 2014
4NGE
DownloadVisualize
BU of 4nge by Molmil
Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)
分子名称: ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ...
著者King, J.V, Liang, W.G, Tang, W.J.
登録日2013-11-01
公開日2014-05-14
最終更新日2014-07-23
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献Molecular basis of substrate recognition and degradation by human presequence protease.
Structure, 22, 2014
4OU0
DownloadVisualize
BU of 4ou0 by Molmil
Crystal Structure of RPA32C
分子名称: Replication protein A 32 kDa subunit
著者Feldkamp, M.D, Mason, A.C, Eichman, B.F, Chazin, W.J.
登録日2014-02-14
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural Analysis of Replication Protein A Recruitment of the DNA Damage Response Protein SMARCAL1.
Biochemistry, 53, 2014
4QIA
DownloadVisualize
BU of 4qia by Molmil
Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor N-benzyl-N-(carboxymethyl)glycyl-L-histidine
分子名称: Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2014-05-30
公開日2015-05-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
4O0A
DownloadVisualize
BU of 4o0a by Molmil
Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
分子名称: 5-{4-[({[4-(5-carboxyfuran-2-yl)-2-chlorophenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Kennedy, J.P, Waterson, A.G, Olejniczak, E.T, Pelz, N.F, Patrone, J.D, Vangamudi, B, Camper, D.V, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2013-12-13
公開日2014-01-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.
J. Med. Chem., 56, 2013
4RE9
DownloadVisualize
BU of 4re9 by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ...
著者Liang, W.G, Deprez, R, Deprez, B, Tang, W.J.
登録日2014-09-22
公開日2015-09-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.908 Å)
主引用文献Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4ND4
DownloadVisualize
BU of 4nd4 by Molmil
Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor (b-nicotinamide adenine dinucleotide)
分子名称: GLYCEROL, Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase, ...
著者Chattopadhyay, D, Cook, W.J.
登録日2013-10-25
公開日2014-12-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Biochemical and structural characterization of Cryptosporidium parvum Lactate dehydrogenase.
Int.J.Biol.Macromol., 74C, 2014
4R4Q
DownloadVisualize
BU of 4r4q by Molmil
Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-[4-({acetyl[4-(5-carboxyfuran-2-yl)benzyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R5R
DownloadVisualize
BU of 4r5r by Molmil
Crystal structure of Rhodostomin KKKRT mutant
分子名称: Disintegrin rhodostomin
著者Huang, C.H, Shiu, J.H, Chang, Y.T, Jeng, W.Y, Chuang, W.J.
登録日2014-08-21
公開日2015-08-26
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (0.96 Å)
主引用文献Effects of the regions adjacent to the RGD motif in disintegrins on their inhibitory activities and structures
To be Published
4R4C
DownloadVisualize
BU of 4r4c by Molmil
Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)-2-chlorobenzamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-[4-({[4-(5-carboxyfuran-2-yl)-2-chlorobenzoyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4PHC
DownloadVisualize
BU of 4phc by Molmil
Crystal Structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound
分子名称: GLYCEROL, HISTIDINE, Histidine--tRNA ligase, ...
著者Koh, C.Y, Wetzel, A.B, de van der Schueren, W.J, Hol, W.G.J.
登録日2014-05-06
公開日2014-08-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.844 Å)
主引用文献Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.
Biochimie, 106, 2014
4REE
DownloadVisualize
BU of 4ree by Molmil
Crystal Structure of TR3 LBD in complex with Molecule 6
分子名称: 1-(2,3,4-trihydroxyphenyl)nonan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1
著者Li, F.W, Cai, Q.X, Li, A.Z, Tian, X.Y, Wang, W.J, Yuan, W, Hou, P.P, Wu, Q, Lin, T.W.
登録日2014-09-22
公開日2015-09-09
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
Chem.Biol., 22, 2015
4R5U
DownloadVisualize
BU of 4r5u by Molmil
Crystal structure of Rhodostomin R46E mutant
分子名称: Disintegrin rhodostomin
著者Huang, C.H, Shiu, J.H, Chang, Y.T, Jeng, W.Y, Chuang, W.J.
登録日2014-08-22
公開日2015-08-26
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Effects of the regions adjacent to the RGD motif in disintegrins on their inhibitory activities and structures
To be Published
4RA8
DownloadVisualize
BU of 4ra8 by Molmil
Structure analysis of the Mip1a P8A mutant
分子名称: C-C motif chemokine 3
著者Liang, W.G, Ren, M, Guo, Q, Tang, W.J.
登録日2014-09-09
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4RAL
DownloadVisualize
BU of 4ral by Molmil
Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta
分子名称: C-C motif chemokine 4, Insulin-degrading enzyme, ZINC ION
著者Liang, W.G, Ren, M, Guo, Q, Tang, W.J.
登録日2014-09-10
公開日2015-05-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.148 Å)
主引用文献Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4REF
DownloadVisualize
BU of 4ref by Molmil
Crystal Structure of TR3 LBD_L449W in complex with Molecule 2
分子名称: 1-(3,4,5-trihydroxyphenyl)hexan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1
著者Li, F.W, Cai, Q.X, Li, A.Z, Tian, X.Y, Wang, W.J, Yuan, W, Hou, P.P, Wu, Q, Lin, T.W.
登録日2014-09-22
公開日2015-09-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
Chem.Biol., 22, 2015
4R4I
DownloadVisualize
BU of 4r4i by Molmil
Structure of RPA70N in complex with 5-(4-((6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-(4-{[6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl]methyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4O
DownloadVisualize
BU of 4r4o by Molmil
Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamothioyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-(4-{[4-(5-carboxyfuran-2-yl)benzyl]carbamothioyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4T
DownloadVisualize
BU of 4r4t by Molmil
Crystal Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)phenylthioamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-{4-[({[4-(5-carboxyfuran-2-yl)phenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4RPU
DownloadVisualize
BU of 4rpu by Molmil
Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60
分子名称: ACETATE ION, CALCIUM ION, GLYCEROL, ...
著者Mo, S.M, Liang, W.G, King, J.V, Wijaya, J, Koehler, C.M, Tang, W.J.
登録日2014-10-31
公開日2015-12-09
実験手法X-RAY DIFFRACTION (2.265 Å)
主引用文献Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60
TO BE PUBLISHED
4RQG
DownloadVisualize
BU of 4rqg by Molmil
Crystal structure of Rhodostomin
分子名称: Disintegrin rhodostomin
著者Shiu, J.H, Huang, C.H, Chang, Y.T, Jeng, W.Y, Chuang, W.J.
登録日2014-11-03
公開日2015-11-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Effects of the regions adjacent to the RGD motif in disintegrins on their inhibitory activities and structures
To be Published
9BJU
DownloadVisualize
BU of 9bju by Molmil
Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
分子名称: 1,2-ETHANEDIOL, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ACETATE ION, ...
著者Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A.
登録日2024-04-25
公開日2024-05-29
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability
To Be Published
1ZHK
DownloadVisualize
BU of 1zhk by Molmil
Crystal structure of HLA-B*3501 presenting 13-mer EBV antigen LPEPLPQGQLTAY
分子名称: Beta-2-microglobulin, EBV-peptide LPEPLPQGQLTAY, HLA class I histocompatibility antigen, ...
著者Tynan, F.E, Borg, N.A, Miles, J.J, Beddoe, T, El-Hassen, D, Silins, S.L, van Zuylen, W.J, Purcell, A.W, Kjer-Nielsen, L, McCluskey, J, Burrows, S.R, Rossjohn, J.
登録日2005-04-26
公開日2005-05-17
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance
J.Biol.Chem., 280, 2005
9BOL
DownloadVisualize
BU of 9bol by Molmil
Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
分子名称: (4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A.
登録日2024-05-03
公開日2024-05-29
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability
To Be Published

223166

件を2024-07-31に公開中

PDB statisticsPDBj update infoContact PDBjnumon