Crystal Structure of TR3 LBD_L449W in complex with Molecule 2

Summary for 4REF

Related4ree 4re8 4whf 4whg
DescriptorNuclear receptor subfamily 4 group A member 1, GLYCEROL, 1-(3,4,5-trihydroxyphenyl)hexan-1-one, ... (4 entities in total)
Functional Keywordslbd, transcription
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P22736
Total number of polymer chains2
Total molecular weight57966.96
Li, F.W.,Cai, Q.X.,Li, A.Z.,Tian, X.Y.,Wang, W.J.,Yuan, W.,Hou, P.P.,Wu, Q.,Lin, T.W. (deposition date: 2014-09-22, release date: 2015-09-09, Last modification date: 2017-11-22)
Primary citation
Wang, W.J.,Wang, Y.,Hou, P.P.,Li, F.W.,Zhou, B.,Chen, H.Z.,Bian, X.L.,Cai, Q.X.,Xing, Y.Z.,He, J.P.,Zhang, H.,Huang, P.Q.,Lin, T.,Wu, Q.
Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
Chem.Biol., 22:1040-1051, 2015
PubMed: 26235054 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2015.06.023
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23370.2%2.3%4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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