4O0A

Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions

Summary for 4O0A

Entry DOI	10.2210/pdb4o0a/pdb
Related	4luo 4luv 4luz 4lwc 4lwi
Descriptor	Replication protein A 70 kDa DNA-binding subunit, 5-{4-[({[4-(5-carboxyfuran-2-yl)-2-chlorophenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid (3 entities in total)
Functional Keywords	ob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	14124.62
Authors	Feldkamp, M.D.,Frank, A.O.,Kennedy, J.P.,Waterson, A.G.,Olejniczak, E.T.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2013-12-13, release date: 2014-01-08, Last modification date: 2023-09-20)
Primary citation	Frank, A.O.,Feldkamp, M.D.,Kennedy, J.P.,Waterson, A.G.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W. Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J. Med. Chem., 56:9242-9250, 2013 Cited by PubMed: 24147804 DOI: 10.1021/jm401333u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation