4LWC
Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
Summary for 4LWC
Entry DOI | 10.2210/pdb4lwc/pdb |
Related | 4LUO 4LUV 4LUZ 4LWI |
Descriptor | Replication protein A 70 kDa DNA-binding subunit, 5-[3-chloro-4-({4-[1-(3,4-dichlorophenyl)-1H-pyrazol-5-yl]benzyl}carbamothioyl)phenyl]furan-2-carboxylic acid (3 entities in total) |
Functional Keywords | ob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P27694 |
Total number of polymer chains | 1 |
Total formula weight | 14080.61 |
Authors | Feldkamp, M.D.,Frank, A.O.,Kennedy, J.P.,Waterson, A.G.,Olejnczak, E.O.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2013-07-26, release date: 2013-12-11, Last modification date: 2023-09-20) |
Primary citation | Frank, A.O.,Feldkamp, M.D.,Kennedy, J.P.,Waterson, A.G.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W. Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J.Med.Chem., 56:9242-9250, 2013 Cited by PubMed: 24147804DOI: 10.1021/jm401333u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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