4LWC
Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Replication protein A 70 kDa DNA-binding subunit | polymer | 123 | 13497.7 | 1 | UniProt (P27694) Pfam (PF04057) | Homo sapiens (human) | RP-A p70, Replication factor A protein 1, RF-A protein 1, Single-stranded DNA-binding protein, Replication protein A 70 kDa DNA-binding subunit, N-terminally processed |
| 2 | B (A) | 5-[3-chloro-4-({4-[1-(3,4-dichlorophenyl)-1H-pyrazol-5-yl]benzyl}carbamothioyl)phenyl]furan-2-carboxylic acid | non-polymer | 582.9 | 1 | Chemie (1XU) | |||
| 3 | C (A) | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
A: 1 - 120 (UniProt: P27694)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Arg 7 | Glu 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13497.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 582.9 | |
| All* | Total formula weight | 14080.6 |
