4DZD
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4N0G
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![BU of 4n0g by Molmil](/molmil-images/mine/4n0g) | Crystal Structure of PYL13-PP2CA complex | Descriptor: | Abscisic acid receptor PYL13, MAGNESIUM ION, Protein phosphatase 2C 37, ... | Authors: | Li, W, Wang, L, Sheng, X, Yan, C, Zhou, R, Hang, J, Yin, P, Yan, N. | Deposit date: | 2013-10-01 | Release date: | 2013-11-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.382 Å) | Cite: | Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13 Cell Res., 23, 2013
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4N0B
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![BU of 4n0b by Molmil](/molmil-images/mine/4n0b) | Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of GabT | Descriptor: | ACETYL GROUP, CALCIUM ION, HTH-type transcriptional regulatory protein GabR, ... | Authors: | Edayathumangalam, R, Wu, R, Garcia, R, Wang, Y, Wang, W, Kreinbring, C.A, Bach, A, Liao, J, Stone, T, Terwilliger, T, Hoang, Q.Q, Belitsky, B.R, Petsko, G.A, Ringe, D, Liu, D. | Deposit date: | 2013-10-01 | Release date: | 2013-10-30 | Last modified: | 2014-04-02 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT. Proc.Natl.Acad.Sci.USA, 110, 2013
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4DFP
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![BU of 4dfp by Molmil](/molmil-images/mine/4dfp) | Crystal structure of the large fragment of DNA Polymerase I from Thermus aqauticus in a ternary complex with 7-(aminopentinyl)-7-deaza-dGTP | Descriptor: | 1,2-ETHANEDIOL, 2-amino-5-(5-aminopent-1-yn-1-yl)-7-{2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, 5'-d(AAACGGCGCCGTGGTC)-3', ... | Authors: | Bergen, K, Steck, A, Struett, S, Baccaro, A, Welte, W, Diederichs, K, Marx, A. | Deposit date: | 2012-01-24 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7-Deazapurine Nucleoside Triphosphates. J.Am.Chem.Soc., 134, 2012
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4N77
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4LHF
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![BU of 4lhf by Molmil](/molmil-images/mine/4lhf) | Crystal structure of a DNA binding protein from phage P2 | Descriptor: | Regulatory protein cox | Authors: | Berntsson, R.P.-A, Odegrip, R, Sehlen, W, Skaar, K, Svensson, L.M, Massad, T, Haggard-Ljungquist, E, Stenmark, P. | Deposit date: | 2013-07-01 | Release date: | 2014-03-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structural insight into DNA binding and oligomerization of the multifunctional Cox protein of bacteriophage P2. Nucleic Acids Res., 42, 2014
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4LAN
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![BU of 4lan by Molmil](/molmil-images/mine/4lan) | Crystal structure of Cordyceps militaris IDCase H195A mutant | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION | Authors: | Xu, S, Li, W, Zhu, J, Ding, J. | Deposit date: | 2013-06-20 | Release date: | 2013-10-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res., 23, 2013
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4DRZ
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![BU of 4drz by Molmil](/molmil-images/mine/4drz) | Crystal structure of human RAB14 | Descriptor: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-14 | Authors: | Wang, J, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-02-17 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of human RAB14 to be published
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4KWT
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![BU of 4kwt by Molmil](/molmil-images/mine/4kwt) | Crystal structure of unliganded anabolic ornithine carbamoyltransferase from Vibrio vulnificus at 1.86 A resolution | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Ornithine carbamoyltransferase | Authors: | Shabalin, I.G, Bacal, P, Bajor, J, Winsor, J, Grimshaw, S, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-05-24 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structures and kinetic properties of anabolic ornithine carbamoyltransferase from human pathogens Vibrio vulnificus and Bacillus anthracis To be Published
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4DQ2
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![BU of 4dq2 by Molmil](/molmil-images/mine/4dq2) | Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp | Descriptor: | ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE, Biotin-[acetyl-CoA-carboxylase] ligase | Authors: | Wilce, M, Yap, M, Pendini, N, Soares de Costa, T, Polyak, S, Tieu, W, Booker, G, Wallace, J. | Deposit date: | 2012-02-14 | Release date: | 2012-04-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287, 2012
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4DSO
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![BU of 4dso by Molmil](/molmil-images/mine/4dso) | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, BENZAMIDINE, GLYCEROL, ... | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | Deposit date: | 2012-02-19 | Release date: | 2012-04-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DSU
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![BU of 4dsu by Molmil](/molmil-images/mine/4dsu) | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | Descriptor: | BENZIMIDAZOLE, GTPase KRas, isoform 2B, ... | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | Deposit date: | 2012-02-19 | Release date: | 2012-04-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4KWE
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![BU of 4kwe by Molmil](/molmil-images/mine/4kwe) | GDP-bound, double-stranded, curved FtsZ protofilament structure | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | Authors: | Li, Y, Hsin, J, Zhao, L, Cheng, Y, Shang, W, Huang, K.C, Wang, H.W, Ye, S. | Deposit date: | 2013-05-23 | Release date: | 2013-07-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation Science, 341, 2013
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4DY0
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![BU of 4dy0 by Molmil](/molmil-images/mine/4dy0) | Crystal structure of native protease nexin-1 with heparin | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ... | Authors: | Huntington, J.A, Li, W. | Deposit date: | 2012-02-28 | Release date: | 2012-08-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism. Blood, 120, 2012
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4L1F
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![BU of 4l1f by Molmil](/molmil-images/mine/4l1f) | Electron transferring flavoprotein of Acidaminococcus fermentans: Towards a mechanism of flavin-based electron bifurcation | Descriptor: | 1,3-PROPANDIOL, Acyl-CoA dehydrogenase domain protein, COENZYME A PERSULFIDE, ... | Authors: | Mowafy, A.M, Chowdhury, N.P, Demmer, J, Upadhyay, V, Kolzer, S, Jayamani, E, Kahnt, J, Demmer, U, Ermler, U, Buckel, W. | Deposit date: | 2013-06-03 | Release date: | 2014-01-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Studies on the Mechanism of Electron Bifurcation Catalyzed by Electron Transferring Flavoprotein (Etf) and Butyryl-CoA Dehydrogenase (Bcd) of Acidaminococcus fermentans. J.Biol.Chem., 289, 2014
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4EC6
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![BU of 4ec6 by Molmil](/molmil-images/mine/4ec6) | Ntf2-like, potential transfer protein TraM from Gram-positive conjugative plasmid pIP501 | Descriptor: | Putative uncharacterized protein | Authors: | Goessweiner-Mohr, N, Grumet, L, Pavkov-Keller, T, Wang, M, Keller, W. | Deposit date: | 2012-03-26 | Release date: | 2012-12-05 | Last modified: | 2013-02-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The 2.5 A Structure of the Enterococcus Conjugation Protein TraM resembles VirB8 Type IV Secretion Proteins. J.Biol.Chem., 288, 2013
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4EF4
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![BU of 4ef4 by Molmil](/molmil-images/mine/4ef4) | Crystal structure of STING CTD complex with c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173 | Authors: | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | Deposit date: | 2012-03-29 | Release date: | 2012-05-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.147 Å) | Cite: | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding Immunity, 36, 2012
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4L8A
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![BU of 4l8a by Molmil](/molmil-images/mine/4l8a) | Crystal structure of a GNAT superfamily acetyltransferase PA4794 in ternary complex with N-Phenylacetyl-Gly-AcLys and CoA | Descriptor: | 1,2-ETHANEDIOL, COENZYME A, N-(phenylacetyl)glycyl-N~6~-acetyl-L-lysine, ... | Authors: | Majorek, K.A, Chruszcz, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2013-06-16 | Release date: | 2013-07-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa. J.Biol.Chem., 288, 2013
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1G0V
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![BU of 1g0v by Molmil](/molmil-images/mine/1g0v) | THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT, MVV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEASE A INHIBITOR 3, PROTEINASE A, ... | Authors: | Phylip, L.H, Lees, W, Brownsey, B.G, Bur, D, Dunn, B.M, Winther, J, Gustchina, A, Li, M, Copeland, T, Wlodawer, A, Kay, J. | Deposit date: | 2000-10-09 | Release date: | 2001-04-21 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae. J.Biol.Chem., 276, 2001
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4N7D
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![BU of 4n7d by Molmil](/molmil-images/mine/4n7d) | Selenomethionine incorporated Bla g 4 | Descriptor: | Bla g 4 allergen variant 1, CITRIC ACID, GLYCEROL | Authors: | Offermann, L.R, Chan, S.L, Osinski, T, Tan, Y.W, Chew, F.T, Sivaraman, J, Mok, Y.K, Minor, W, Chruszcz, M. | Deposit date: | 2013-10-15 | Release date: | 2014-05-21 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The major cockroach allergen Bla g 4 binds tyramine and octopamine. Mol.Immunol., 60, 2014
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4MTL
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![BU of 4mtl by Molmil](/molmil-images/mine/4mtl) | Human Methyltransferase-Like Protein 21C | Descriptor: | Protein-lysine methyltransferase METTL21C, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION | Authors: | Hong, B.S, Tempel, W, Dong, A, Li, Y, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2013-09-19 | Release date: | 2013-10-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Human Methyltransferase-Like Protein 21C To be Published
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4N7V
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![BU of 4n7v by Molmil](/molmil-images/mine/4n7v) | Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152 N-terminal fragment | Descriptor: | Centrosomal protein of 152 kDa, Serine/threonine-protein kinase PLK4 | Authors: | Park, S.-Y, Park, J.-E, Tian, L, Kim, T.-S, Yang, W, Lee, K.S. | Deposit date: | 2013-10-16 | Release date: | 2014-07-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.758 Å) | Cite: | Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat.Struct.Mol.Biol., 21, 2014
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4N9D
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![BU of 4n9d by Molmil](/molmil-images/mine/4n9d) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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4ECZ
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![BU of 4ecz by Molmil](/molmil-images/mine/4ecz) | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.5 (Na+ MES) with 1 Ca2+ ion | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Nakamura, T, Zhao, Y, Yang, W. | Deposit date: | 2012-03-26 | Release date: | 2012-07-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.834 Å) | Cite: | Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
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4NA5
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![BU of 4na5 by Molmil](/molmil-images/mine/4na5) | |