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4N9D

Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Summary for 4N9D
Entry DOI10.2210/pdb4n9d/pdb
Related4N9B 4N9C
DescriptorNicotinamide phosphoribosyltransferase, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordstransferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P43490
Total number of polymer chains2
Total formula weight115294.16
Authors
Primary citationDragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.C.,Hua, R.,Li, G.,Liang, X.,Ma, X.,O'Brien, T.,Oh, A.,Skelton, N.J.,Wang, C.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhao, Q.,Zheng, X.
Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24:954-962, 2014
Cited by
PubMed: 24433859
DOI: 10.1016/j.bmcl.2013.12.062
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.701 Å)
Structure validation

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