4N9B
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Summary for 4N9B
Entry DOI | 10.2210/pdb4n9b/pdb |
Related | 4N9C 4N9D 4N9E |
Descriptor | Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1-methyl-N-(pyridin-3-yl)-1H-pyrazole-5-carboxamide, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 114479.12 |
Authors | Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.,Hua, R.,Li, G.,Liang, X.,O'Brien, T.,Skelton, N.J.,Wang, C.,Zhai, Q.,Oh, A.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.,Zak, M.,Zheng, X. (deposition date: 2013-10-20, release date: 2014-02-19, Last modification date: 2023-09-20) |
Primary citation | Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.C.,Hua, R.,Li, G.,Liang, X.,Ma, X.,O'Brien, T.,Oh, A.,Skelton, N.J.,Wang, C.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhao, Q.,Zheng, X. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24:954-962, 2014 Cited by PubMed: 24433859DOI: 10.1016/j.bmcl.2013.12.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.859 Å) |
Structure validation
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